Zhang Linlin, Chen Jun, Li Fuxingzi, Liu Binjie, Liu Junjie
Hunan Key Laboratory of Oral Health Research, Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Central South University, Changsha, China.
Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Physiol. 2025 Mar 6;16:1501158. doi: 10.3389/fphys.2025.1501158. eCollection 2025.
Animal models of oral submucous fibrosis (OSF) are essential for the studying on the pathogenesis of this disease. Current research on animal models of OSF requires further investigation. In this review, we aim to summarize the strengths and weaknesses of existing OSF animal models, as well as the recent progress in this field.
OSF is an oral potentially malignant disorder (OPMD) characterized by fibrotic bands, burning sensations, and limited mouth opening. Numerous experimental animal models have been developed to replicate the pathological processes in patients with OSF. Therefore, we systematically evaluated existing animal models of OSF classifying them according to the elements of building an animal model.
In this study, we propose that the elements of animal models for OSF include inducers, animal species, and methods of intervention. Additionally, we highlighted the advantages and limitations of these models and provided directions for future research.
Using human-like animals as experimental subjects, combining both physical and chemical stimulation, and adjusting the dosage and type of inducer may represent the direction of future studies in this field.
口腔黏膜下纤维化（OSF）动物模型对于研究该疾病的发病机制至关重要。目前对OSF动物模型的研究仍需进一步探索。在本综述中，我们旨在总结现有OSF动物模型的优缺点以及该领域的最新进展。
OSF是一种口腔潜在恶性疾病（OPMD），其特征为纤维化条索、烧灼感和张口受限。已经建立了许多实验动物模型来复制OSF患者的病理过程。因此，我们根据构建动物模型的要素对现有的OSF动物模型进行了系统评估。
在本研究中，我们提出OSF动物模型的要素包括诱导剂、动物种类和干预方法。此外，我们强调了这些模型的优点和局限性，并为未来的研究提供了方向。
以类人动物作为实验对象，结合物理和化学刺激，并调整诱导剂的剂量和类型，可能代表该领域未来研究的方向。
