Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China.
Department of Hospital Infection Control, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Int J Cardiol. 2022 Aug 15;361:61-69. doi: 10.1016/j.ijcard.2022.05.025. Epub 2022 May 17.
Cardiovascular disease(CVD)is one of the predominant causes of death and morbidity. Mitochondria play a key role in maintaining cardiac energy metabolism. However, mitochondrial dysfunction leads to excessive production of ROS, resulting in oxidative damage to cardiomyocytes and contributing to a variety of cardiovascular diseases. In such a case, the clearance of impaired mitochondria is necessary. Currently, most studies have indicated an essential role for mitophagy in maintaining cardiac homeostasis and regulating CVD-related metabolic transition. Recent studies have implicated that PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy has been implicated in maintaining cardiomyocyte homeostasis. Here, we discuss the physiological and pathological roles of PINK1/Parkin-mediated mitophagy in the cardiovascular system, as well as potential therapeutic strategies based on PINK1/Parkin-mediated mitophagy modulation, which are of great significance for the prevention and treatment of cardiovascular diseases.
心血管疾病（CVD）是死亡和发病的主要原因之一。线粒体在维持心脏能量代谢方面起着关键作用。然而，线粒体功能障碍会导致 ROS 的过度产生，从而导致心肌细胞的氧化损伤，并导致多种心血管疾病。在这种情况下，必须清除受损的线粒体。目前，大多数研究表明，自噬在维持心脏内稳态和调节与 CVD 相关的代谢转换中起着重要作用。最近的研究表明，PTEN 诱导的假定激酶 1（PINK1）/Parkin 介导的线粒体自噬在维持心肌细胞内稳态中起着重要作用。在这里，我们讨论了 PINK1/Parkin 介导的线粒体自噬在心血管系统中的生理和病理作用，以及基于 PINK1/Parkin 介导的线粒体自噬调节的潜在治疗策略，这对于心血管疾病的预防和治疗具有重要意义。
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