Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Autoimmun Rev. 2022 Jul;21(7):103118. doi: 10.1016/j.autrev.2022.103118. Epub 2022 May 18.
Paralleling advances with respect to more common antibody-mediated encephalitides, such as anti-N-methyl-D-aspartate receptor (NMDAR) and anti-leucine-rich glioma-inactivated 1 (LGI1) Ab-mediated encephalitis, the discovery and characterisation of novel antibody-mediated encephalitides accelerated over the past decade, adding further depth etiologically to the spectrum of antibody-mediated encephalitis. Herein, we review the major mechanistic, clinical features and management considerations with respect to anti-γ-aminobutyric acid B (GABA)-, anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropinoic receptor- (AMPAR), anti-GABA-, anti-dipeptidyl-peptidase-like protein-6 (DPPX) Ab-mediated encephalitides, delineate rarer subtypes and summarise findings to date regarding seronegative autoimmune encephalitis.
与更常见的抗体介导的脑炎（如抗 N-甲基-D-天冬氨酸受体[NMDAR]和抗亮氨酸丰富的胶质瘤失活 1[LGI1]Ab 介导的脑炎）的进展相平行，在过去十年中，新型抗体介导的脑炎的发现和特征得到了加速，这进一步从病因学上加深了抗体介导的脑炎的谱。在此，我们回顾了抗 γ-氨基丁酸 B（GABA）-、抗 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体-（AMPAR）-、抗 GABA-、抗二肽基肽酶样蛋白 6（DPPX）Ab 介导的脑炎的主要发病机制、临床特征和治疗注意事项，阐述了更罕见的亚型，并总结了目前关于血清阴性自身免疫性脑炎的研究结果。
