Division of Allergy and Clinical immunology, Bnai-Zion Medical Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Division of Allergy and Clinical immunology, Bnai-Zion Medical Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Autoimmun Rev. 2022 Jul;21(7):103116. doi: 10.1016/j.autrev.2022.103116. Epub 2022 May 17.
B cells are major players in immune responses being the source of protective antibodies and antigen presenting cells. When self-tolerance fails, auto reactive B cells produce autoantibodies and pro-inflammatory cytokines leading to the development of autoimmune diseases. Many recent studies have assessed importance of metabolic pathways in B cells, demonstrating their role in controlling autoimmunity and maintaining immune homeostasis. Alterations in B cell functions in autoimmune diseases are closely associated with abnormal metabolic shifts, allowing auto reactive B cells to escape tolerogenic checkpoints. Understanding the metabolic changes in B cells, opens up new possibilities for targeting metabolic pathways and manipulating metabolic avenues as a therapeutic strategy for the treatment of autoimmune diseases.
B 细胞是免疫反应的主要参与者，是保护性抗体和抗原呈递细胞的来源。当自身耐受失败时，自身反应性 B 细胞产生自身抗体和促炎细胞因子，导致自身免疫性疾病的发展。许多最近的研究评估了代谢途径在 B 细胞中的重要性，证明了它们在控制自身免疫和维持免疫稳态中的作用。自身免疫性疾病中 B 细胞功能的改变与异常代谢转变密切相关，使自身反应性 B 细胞逃避耐受检查点。了解 B 细胞中的代谢变化为靶向代谢途径和操纵代谢途径开辟了新的可能性，作为治疗自身免疫性疾病的治疗策略。
