National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiangya School of Public Health, Central South University, Changsha, China.
Front Immunol. 2023 Aug 23;14:1232820. doi: 10.3389/fimmu.2023.1232820. eCollection 2023.
Autoimmune diseases are heterogeneous disorders believed to stem from the immune system's inability to distinguish between auto- and foreign- antigens. B lymphocytes serve a crucial role in humoral immunity as they generate antibodies and present antigens. Dysregulation of B cell function induce the onset of autoimmune disorders by generating autoantibodies and pro-inflammatory cytokines, resulting in an imbalance in immune regulation. New research in immunometabolism shows that cellular metabolism plays an essential role in controlling B lymphocytes immune reactions by providing the energy and substrates for B lymphocytes activation, differentiation, and function. However, dysregulated immunometabolism lead to autoimmune diseases by disrupting self-tolerance mechanisms. This review summarizes the latest research on metabolic reprogramming of B lymphocytes in autoimmune diseases, identifying crucial pathways and regulatory factors. Moreover, we consider the potential of metabolic interventions as a promising therapeutic strategy. Understanding the metabolic mechanisms of B cells brings us closer to developing novel therapies for autoimmune disorders.
自身免疫性疾病是一种异质性疾病，据信源于免疫系统无法区分自身抗原和外来抗原。B 淋巴细胞在体液免疫中起着至关重要的作用，因为它们产生抗体并呈递抗原。B 细胞功能失调会通过产生自身抗体和促炎细胞因子导致自身免疫性疾病的发生，从而导致免疫调节失衡。免疫代谢的新研究表明，细胞代谢通过为 B 淋巴细胞的激活、分化和功能提供能量和底物，在控制 B 淋巴细胞免疫反应方面发挥着重要作用。然而，代谢失调会通过破坏自身耐受机制导致自身免疫性疾病。本综述总结了自身免疫性疾病中 B 淋巴细胞代谢重编程的最新研究，确定了关键途径和调节因子。此外，我们还考虑了代谢干预作为一种有前途的治疗策略的潜力。了解 B 细胞的代谢机制使我们更接近于为自身免疫性疾病开发新的治疗方法。
