Changchun Veterinary Research Institute, Chinese Academy of Agricultural Science, Changchun, 130122, China.
Jilin Medical University, Jilin, 132013, China.
Toxicon. 2022 Jul 30;214:47-53. doi: 10.1016/j.toxicon.2022.05.005. Epub 2022 May 17.
Ricin toxin (RT) belongs to the ribosome-inactivating protein (RIP) family of toxins and is considered to be a moderate threat by the US Center of Disease Control and Prevention (CDC). RT poses a great potential threat to the public, but there has been a lack of effective treatment options so far. Over the past few decades, researches on the prevention and treatment of RT poisoning have been investigated, among which neutralizing antibodies targeting RT specifically have always been a research hotspot. In this review, we have summarized the mechanism of action of RT, the research results and the design strategies of RT neutralizing antibodies, and discussed the key issues in the development of RT neutralizing antibody researches.
蓖麻毒素（RT）属于核糖体失活蛋白（RIP）家族的毒素，被美国疾病控制与预防中心（CDC）认为是中度威胁。RT 对公众构成了巨大的潜在威胁，但到目前为止，还缺乏有效的治疗选择。在过去的几十年中，人们一直在研究 RT 中毒的预防和治疗方法，其中针对 RT 的中和抗体一直是研究热点。在这篇综述中，我们总结了 RT 的作用机制、RT 中和抗体的研究结果和设计策略，并讨论了 RT 中和抗体研究开发中的关键问题。
