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锌(II)-酞菁在均相和微非均相体系中的光谱研究。

Spectroscopic studies on Zn(II)-phthalocyanine in homogeneous and microheterogeneous systems.

作者信息

Valduga G, Reddi E, Jori G

出版信息

J Inorg Biochem. 1987 Jan;29(1):59-65. doi: 10.1016/0162-0134(87)80012-0.

DOI:10.1016/0162-0134(87)80012-0
PMID:3559547
Abstract

The absorption and fluorescence properties of Zn2+-phthalocyanine (Zn-Pc) have been characterized in homogeneous and microheterogeneous media. By our preparation procedure, the phthalocyanine can be associated in a monomeric state with cationic micelles, unilamellar liposomes, and low-density lipoproteins; the distribution of Zn-Pc in the hydrophobic phases appears to be controlled by the nature of the lipid environment. The potential use of liposome-bound Zn-Pc for photosensitization studies in aqueous media and for phototherapeutic applications in vivo is briefly discussed.

摘要

锌酞菁(Zn-Pc)在均相和微非均相介质中的吸收和荧光特性已得到表征。通过我们的制备方法,酞菁可以以单体状态与阳离子胶束、单层脂质体和低密度脂蛋白结合;Zn-Pc在疏水相中的分布似乎受脂质环境性质的控制。本文简要讨论了脂质体结合的Zn-Pc在水性介质中用于光敏化研究以及在体内用于光治疗应用的潜在用途。

相似文献

1
Spectroscopic studies on Zn(II)-phthalocyanine in homogeneous and microheterogeneous systems.锌(II)-酞菁在均相和微非均相体系中的光谱研究。
J Inorg Biochem. 1987 Jan;29(1):59-65. doi: 10.1016/0162-0134(87)80012-0.
2
Steady state and time-resolved spectroscopic studies on zinc(II) phthalocyanine in liposomes.脂质体中锌(II)酞菁的稳态和时间分辨光谱研究。
J Photochem Photobiol B. 1992 Dec;16(3-4):331-40. doi: 10.1016/1011-1344(92)80020-v.
3
In vitro interaction of zinc(II)-phthalocyanine-containing liposomes and plasma lipoproteins.
J Photochem Photobiol B. 1994 Oct;26(1):29-35. doi: 10.1016/1011-1344(94)85033-x.
4
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.脂质体或低密度脂蛋白给药的锌(II)-酞菁作为肿瘤光动力剂。I. 药代动力学性质和光疗效率。
Br J Cancer. 1990 Mar;61(3):407-11. doi: 10.1038/bjc.1990.89.
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Interaction between zinc(II)-phthalocyanine-containing liposomes and human low density lipoprotein.
J Photochem Photobiol B. 1994 May;23(2-3):141-8. doi: 10.1016/1011-1344(94)06998-0.
6
The effect of different liposomal formulations on the interaction of Zn(II)-phthalocyanine with isolated low and high density lipoproteins.不同脂质体制剂对锌(II)-酞菁与分离的低密度和高密度脂蛋白相互作用的影响。
Int J Biochem Cell Biol. 1995 Dec;27(12):1249-55. doi: 10.1016/1357-2725(95)00107-Z.
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The distribution of the tumour photosensitizers Zn(II)-phthalocyanine and Sn(IV)-etiopurpurin among rabbit plasma proteins.肿瘤光敏剂锌(II)-酞菁和锡(IV)-etiopurpurin在兔血浆蛋白中的分布。
Cancer Lett. 1992 Oct 21;66(3):217-23. doi: 10.1016/0304-3835(92)90250-y.
8
Targeting of experimentally induced atherosclerotic lesions by liposome-delivered Zn(II)-phthalocyanine.
Atherosclerosis. 1993 May;100(2):213-22. doi: 10.1016/0021-9150(93)90207-b.
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Delivery of the tumour photosensitizer zinc(II)-phthalocyanine to serum proteins by different liposomes: studies in vitro and in vivo.不同脂质体将肿瘤光敏剂锌(II)-酞菁递送至血清蛋白的研究:体内外研究
Cancer Lett. 1990 Jan;49(1):59-65. doi: 10.1016/0304-3835(90)90139-o.
10
Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.锌(II)-酞菁在荷瘤小鼠体内的药代动力学研究。
Br J Cancer. 1987 Nov;56(5):597-600. doi: 10.1038/bjc.1987.247.

引用本文的文献

1
In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes.脂质体包裹的酞菁锌的体内荧光及光动力活性
Br J Cancer. 1994 May;69(5):840-5. doi: 10.1038/bjc.1994.163.
2
Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.锌(II)-酞菁在荷瘤小鼠体内的药代动力学研究。
Br J Cancer. 1987 Nov;56(5):597-600. doi: 10.1038/bjc.1987.247.
3
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.
脂质体或低密度脂蛋白给药的锌(II)-酞菁作为肿瘤光动力剂。I. 药代动力学性质和光疗效率。
Br J Cancer. 1990 Mar;61(3):407-11. doi: 10.1038/bjc.1990.89.