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1
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.脂质体或低密度脂蛋白给药的锌（II）-酞菁作为肿瘤光动力剂。I. 药代动力学性质和光疗效率。
Br J Cancer. 1990 Mar;61(3):407-11. doi: 10.1038/bjc.1990.89.
2
Effect of axial ligation and delivery system on the tumour-localising and -photosensitising properties of Ge(IV)-octabutoxy-phthalocyanines.轴向结扎与递送系统对锗（IV）-八丁氧基-酞菁的肿瘤定位及光敏特性的影响
Br J Cancer. 1995 Apr;71(4):727-32. doi: 10.1038/bjc.1995.142.
3
Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosis.锌（II）-酞菁作为肿瘤的光动力剂。II. 光致敏肿瘤坏死机制的研究。
Br J Cancer. 1990 Jun;61(6):846-50. doi: 10.1038/bjc.1990.189.
4
Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.锌（II）-酞菁在荷瘤小鼠体内的药代动力学研究。
Br J Cancer. 1987 Nov;56(5):597-600. doi: 10.1038/bjc.1987.247.
5
Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine.脂质体递送的四价锗-八丁氧基-酞菁的肿瘤定位和光敏特性
Br J Cancer. 1991 Jul;64(1):93-5. doi: 10.1038/bjc.1991.247.
6
Tumour-localising and -photosensitising properties of a novel zinc(II) octadecylphthalocyanine.一种新型锌（II）十八烷基酞菁的肿瘤定位和光敏特性。
Br J Cancer. 1996 Dec;74(12):1891-9. doi: 10.1038/bjc.1996.650.
7
Delivery of the tumour photosensitizer zinc(II)-phthalocyanine to serum proteins by different liposomes: studies in vitro and in vivo.不同脂质体将肿瘤光敏剂锌（II）-酞菁递送至血清蛋白的研究：体内外研究
Cancer Lett. 1990 Jan;49(1):59-65. doi: 10.1016/0304-3835(90)90139-o.
8
Comparative pharmacokinetic and photodynamic studies with zinc(II) phthalocyanine in hamsters bearing an induced or transplanted rhabdomyosarcoma.锌（II）酞菁在诱导或移植横纹肌肉瘤仓鼠中的比较药代动力学和光动力研究。
J Photochem Photobiol B. 1992 Oct 15;16(1):83-9. doi: 10.1016/1011-1344(92)85155-n.
9
Tumour-localizing and tumour-photosensitizing properties of zinc(II)-octapentyl-phthalocyanine.锌（II）-八戊基-酞菁的肿瘤定位和肿瘤光敏特性。
J Photochem Photobiol B. 1997 Jul;39(3):279-84. doi: 10.1016/s1011-1344(97)00018-3.
10
Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies.脂质体递送的硅（IV）-萘酞菁作为实验性肿瘤的光动力敏化剂：药代动力学和光治疗研究
Br J Cancer. 1990 Dec;62(6):966-70. doi: 10.1038/bjc.1990.418.

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Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells.纳米脂质体苯并卟啉衍生物制剂：探索其在卵巢癌细胞治疗指数方面对纳米结构光物理和光化学的依赖性。
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8
Like a bolt from the blue: phthalocyanines in biomedical optics.犹如晴天霹雳：酞菁在生物医学光学中的应用。
Molecules. 2011 Dec 23;17(1):98-144. doi: 10.3390/molecules17010098.
9
Structural and physico-chemical determinants of the interactions of macrocyclic photosensitizers with cells.大环光敏剂与细胞相互作用的结构和物理化学决定因素。
Eur Biophys J. 2007 Nov;36(8):943-53. doi: 10.1007/s00249-007-0204-9. Epub 2007 Jul 13.
10
Serum albumin as a vehicle for zinc phthalocyanine: photodynamic activities in solid tumour models.血清白蛋白作为酞菁锌的载体：实体瘤模型中的光动力活性
Br J Cancer. 1996 Dec;74(12):1886-90. doi: 10.1038/bjc.1996.649.

本文引用的文献

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The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.人血清中超离心分离的脂蛋白的分布及化学组成
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2
Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse.血卟啉衍生物在正常及肿瘤小鼠组织中的放射自显影分布
Cancer Res. 1981 Nov;41(11 Pt 1):4606-12.
3
Photodynamic therapy (PDT) of malignant tumors.恶性肿瘤的光动力疗法（PDT）。
Crit Rev Oncol Hematol. 1984;2(2):83-116. doi: 10.1016/s1040-8428(84)80016-5.
4
Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.血卟啉衍生物与激光光辐射治疗肺癌
Chest. 1982 Mar;81(3):269-77. doi: 10.1378/chest.81.3.269.
5
Synthesis, tissue distribution and tumor uptake of 99mTc- and 67Ga-tetrasulfophthalocyanine.99mTc和67Ga四磺基酞菁的合成、组织分布及肿瘤摄取
Int J Appl Radiat Isot. 1985 Sep;36(9):709-16. doi: 10.1016/0020-708x(85)90041-9.
6
The phthalocyanines: a new class of mammalian cells photosensitizers with a potential for cancer phototherapy.酞菁类化合物：一类新型的哺乳动物细胞光敏剂，具有癌症光动力治疗的潜力。
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Feb;47(2):145-7. doi: 10.1080/09553008514550211.
7
Selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts.培养的成纤维细胞中低密度脂蛋白受体途径对有毒亲脂性蒽环类衍生物的选择性摄取。
J Med Chem. 1985 Apr;28(4):451-4. doi: 10.1021/jm00382a011.
8
Tumor localization and photosensitization by sulfonated derivatives of tetraphenylporphine.四苯基卟啉磺化衍生物的肿瘤定位与光敏作用
Photochem Photobiol. 1987 Jun;45(6):787-90. doi: 10.1111/j.1751-1097.1987.tb07883.x.
9
Biological activities of phthalocyanines--V. Photodynamic therapy of EMT-6 mammary tumors in mice with sulfonated phthalocyanines.酞菁的生物活性——V. 用磺化酞菁对小鼠EMT - 6乳腺肿瘤进行光动力治疗
Photochem Photobiol. 1987 May;45(5):581-6. doi: 10.1111/j.1751-1097.1987.tb07383.x.
10
Photodynamic therapy with phthalocyanine sensitisation: quantitative studies in a transplantable rat fibrosarcoma.酞菁敏化光动力疗法：对可移植大鼠纤维肉瘤的定量研究
Br J Cancer. 1987 Apr;55(4):389-95. doi: 10.1038/bjc.1987.78.

脂质体或低密度脂蛋白给药的锌（II）-酞菁作为肿瘤光动力剂。I. 药代动力学性质和光疗效率。

Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.

作者信息

Reddi E, Zhou C, Biolo R, Menegaldo E, Jori G

机构信息

Department of Biology, University of Padova, Italy.

出版信息

Br J Cancer. 1990 Mar;61(3):407-11. doi: 10.1038/bjc.1990.89.

DOI:10.1038/bjc.1990.89
PMID:2328207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1971303/
Abstract

The pharmacokinetics of Zn-phthalocyanine (Zn-Pc) in mice bearing a transplanted MS-2 fibrosarcoma has been studied using dipalmitoyl-phosphatidylcholine (DPPC) liposomes and low density lipoproteins (LDL) as drug delivery systems. LDL induce a higher Zn-Pc uptake by the tumour and improve the selectivity of tumour targeting as compared to DPPC liposomes. Experimental photodynamic therapy (PDT) of the MS-2 fibrosarcoma has been performed using liposome-delivered Zn-Pc and the efficiency of tumour necrosis has been measured following four different irradiation protocols. We found that Zn-Pc doses as low as 0.07-0.35 mg kg-1 are sufficient for inducing an efficient tumour response that is linearly dependent on the injected dose. The amount of Zn-Pc in the tumour decreases very slowly as a function of time, hence PDT gives satisfactory results even if performed at relatively long time intervals after administration.

摘要

以二棕榈酰磷脂酰胆碱（DPPC）脂质体和低密度脂蛋白（LDL）作为药物递送系统，研究了锌酞菁（Zn-Pc）在移植了MS-2纤维肉瘤的小鼠体内的药代动力学。与DPPC脂质体相比，LDL可诱导肿瘤对Zn-Pc的摄取增加，并提高肿瘤靶向的选择性。使用脂质体递送的Zn-Pc对MS-2纤维肉瘤进行了实验性光动力疗法（PDT），并在四种不同的照射方案后测量了肿瘤坏死的效率。我们发现，低至0.07-0.35 mg kg-1的Zn-Pc剂量足以诱导有效的肿瘤反应，该反应与注射剂量呈线性相关。肿瘤中Zn-Pc的量随时间下降非常缓慢，因此即使在给药后较长时间间隔进行PDT也能取得满意的结果。