结外双打击滤泡性淋巴瘤的不典型表现：一例报告。
Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report.
机构信息
Department of Medical Biotechnology, University of Siena, Siena, Italy.
Institute of Pathology and Neuropathology, Tübingen University Hospital and Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Italy.
出版信息
BMC Gastroenterol. 2022 May 20;22(1):254. doi: 10.1186/s12876-022-02308-8.
BACKGROUND
To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion.
CASE PRESENTATION
A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bearing morphological, immunohistochemical and molecular hallmarks of DH-FL. Complete clinical staging and bone marrow biopsy showed no signs of disseminated disease. The patient, after two years of follow-up is still free of disease confirming the indolent behaviour of this limited lesion.
CONCLUSIONS
A synoptic view at all the features of the patient and not merely at the molecular hallmarks of a disease are essential to establish the correct clinical approach.
背景
据我们所知，本例是首例作为肠息肉样病变的结外双打击滤泡淋巴瘤（DH-FL）病例报告。
病例介绍
一名 72 岁女性因便秘就诊。结肠镜检查显示结肠有一息肉样无蒂病变，具有 DH-FL 的形态学、免疫组化和分子特征。完整的临床分期和骨髓活检均未显示弥散性疾病的迹象。该患者在两年的随访中仍无疾病，证实了这种局限性病变的惰性行为。
结论
综合评估患者的所有特征，而不仅仅是疾病的分子特征，对于确定正确的临床方法至关重要。
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