青少年帕金森病：临床与代谢特征
Juvenile Parkinsonism: clinical and metabolic characteristics.
作者信息
Lima B, Neves G, Nora M
出版信息
J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):345-8. doi: 10.1136/jnnp.50.3.345.
Abstract
Twenty one patients with idiopathic Parkinsonism beginning before the age of 40 years were investigated. The mean duration of the disease was 19 years. There was a good and sustained response to levodopa. Only four patients reached stages IV and V (Hoehn and Yahr). Intolerance to levodopa was observed in the more advanced stages of the disease. In the series the familial incidence of Parkinsonism (2 cases) and essential tremor (3 cases) was very low. Thyroid disorder, diabetes mellitus or macrocytic anaemia was not found in any of the cases.
摘要
对21例40岁以前发病的特发性帕金森病患者进行了调查。疾病的平均病程为19年。左旋多巴治疗反应良好且持续。只有4例患者达到了IV期和V期（霍恩和雅尔分期）。在疾病的较晚期观察到对左旋多巴不耐受。在该系列中，帕金森病（2例）和特发性震颤（3例）的家族发病率非常低。所有病例均未发现甲状腺疾病、糖尿病或大细胞性贫血。
相似文献
1
Juvenile Parkinsonism: clinical and metabolic characteristics.青少年帕金森病：临床与代谢特征
J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):345-8. doi: 10.1136/jnnp.50.3.345.
2
Young onset Parkinson's disease.早发型帕金森病
Mov Disord. 1987;2(2):73-91. doi: 10.1002/mds.870020201.
3
[A case of familial juvenile dystonia-parkinsonism: 18F-6-fluorodopa and 18F-fluoro-2-deoxyglucose PET study].[一例家族性青少年肌张力障碍-帕金森综合征：18F-6-氟多巴和18F-氟代脱氧葡萄糖PET研究]
Rinsho Shinkeigaku. 1996 May;36(5):655-60.
4
Long-term treatment response and fluorodopa positron emission tomographic scanning of parkinsonism in a family with dopa-responsive dystonia.一个患有多巴反应性肌张力障碍的家族中帕金森症的长期治疗反应及氟多巴正电子发射断层扫描
Ann Neurol. 1992 Nov;32(5):603-8. doi: 10.1002/ana.410320502.
5
Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.晚期帕金森病患者左旋多巴的药代动力学-药效学建模
Clin Neuropharmacol. 2010 May;33(3):135-41. doi: 10.1097/WNF.0b013e3181d47849.
6
Clinical course of patients with idiopathic Parkinson's disease.特发性帕金森病患者的临床病程。
Mov Disord. 1996 May;11(3):236-42. doi: 10.1002/mds.870110304.
7
Subthalamic nucleus stimulation for Parkinson disease: benefits observed in levodopa-intolerant patients.丘脑底核刺激治疗帕金森病：在左旋多巴不耐受患者中观察到的益处
J Neurosurg. 2001 Aug;95(2):213-21. doi: 10.3171/jns.2001.95.2.0213.
8
Levodopa pharmacokinetic-pharmacodynamic modeling and 6-[18F]levodopa positron emission tomography in patients with Parkinson's disease.帕金森病患者左旋多巴药代动力学-药效学建模及6-[18F]左旋多巴正电子发射断层扫描
Clin Pharmacol Ther. 2001 Jul;70(1):33-41. doi: 10.1067/mcp.2001.116328.
9
[Apomorphine test: evaluation of dopaminergic response in patients with Parkinson disease].[阿扑吗啡试验：帕金森病患者多巴胺能反应的评估]
Rev Med Chil. 1995 Mar;123(3):326-9.
引用本文的文献
1
Juvenile Parkinson's disease with widespread Lewy bodies in the brain.
Acta Neuropathol. 1988;77(2):213-8. doi: 10.1007/BF00687434.
2
Is Parkinson's disease of early onset a separate disease entity?早发性帕金森病是一种独立的疾病实体吗？
J Neurol. 1989 May;236(4):203-7. doi: 10.1007/BF00314500.
3
Neuropathology in movement disorders.运动障碍中的神经病理学
J Neurol Neurosurg Psychiatry. 1989 Jun;Suppl(Suppl):55-67. doi: 10.1136/jnnp.52.suppl.55.
4
A controlled, longitudinal study of dementia in Parkinson's disease.帕金森病痴呆的一项对照纵向研究。
J Neurol Neurosurg Psychiatry. 1992 Jul;55(7):566-71. doi: 10.1136/jnnp.55.7.566.
本文引用的文献
1
A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study.一种与直立性低血压相关的神经综合征：一项临床病理研究。
Arch Neurol. 1960 May;2:511-27. doi: 10.1001/archneur.1960.03840110025004.
2
ENCEPHALITIS AND PARKINSONISM.脑炎与帕金森症
Arch Neurol. 1965 Mar;12:227-39. doi: 10.1001/archneur.1965.00460270003001.
3
Rigid and akinetic forms of Huntington's chorea.亨廷顿舞蹈症的强直型和运动不能型
Arch Neurol. 1962 Oct;7:275-88. doi: 10.1001/archneur.1962.04210040027003.
4
Parkinsonism-dementia complex, an endemic disease on the island of Guam. II. Pathological features.帕金森病痴呆综合征，关岛岛上的一种地方病。II. 病理特征。
Brain. 1961 Dec;84:662-79. doi: 10.1093/brain/84.4.662.
5
Parkinsonism-dementia complex, an endemic disease on the island of Guam. I. Clinical features.帕金森痴呆综合征，关岛岛上的一种地方病。I. 临床特征。
Brain. 1961 Dec;84:642-61. doi: 10.1093/brain/84.4.642.
6
Familial paralysis agitans juvenilis; a clinical, anatomical and genetic study.家族性青少年帕金森病；一项临床、解剖学和遗传学研究。
Folia Psychiatr Neurol Jpn. 1958 Jul;12(2):112-21. doi: 10.1111/j.1440-1819.1958.tb00623.x.
7
The Kayser-Fleischer ring; a histochemical and electron microscope study.
Neurology. 1957 May;7(5):341-55. doi: 10.1212/wnl.7.5.341.
8
Pallido-pyramidal disease.
J Neuropathol Exp Neurol. 1954 Jan;13(1):50-9. doi: 10.1097/00005072-195401000-00007.
9
Deficiency of ceruloplasmin in patients with hepatolenticular degeneration (Wilson's disease).肝豆状核变性（威尔逊病）患者血浆铜蓝蛋白缺乏。
Science. 1952 Oct 31;116(3018):484-5. doi: 10.1126/science.116.3018.484.
10
Bilateral basal ganglia calcifications visualised on CT scan.CT扫描显示双侧基底节钙化。
J Neurol Neurosurg Psychiatry. 1980 May;43(5):403-6. doi: 10.1136/jnnp.43.5.403.
Zotero 插件