The University of Arizona, Phoenix, USA.
Dignity Health, Phoenix, AZ, USA.
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096211056494. doi: 10.1177/23247096211056494.
Androgen-producing steroid cell ovarian tumors are rare, comprising less than 1% of ovarian neoplasms, and can present with infertility and rapid virilization. Here we discuss the case of a 28-year-old woman who presented with an unusually insidious 2-year history of infertility, hirsutism, and clitoromegaly who was found to have an elevated serum testosterone and a left ovarian mass. She underwent oophorectomy and pathology revealed a steroid cell tumor, not otherwise specified (NOS), with no malignant features. Following surgery, the patient's hyperandrogenic symptoms resolved with normalization of testosterone within 6 months, and she was able to conceive spontaneously. In reproductive-aged women with progressive hyperandrogenic symptoms, androgen-producing tumors, including those of ovarian origin, should be suspected. Thorough investigation, including plasma hormone levels and tumor histology, can lead to accurate diagnosis and management. Treatment should be guided by histology and surgical staging, with consideration for future fertility desires. Women who have not completed childbearing can undergo unilateral oophorectomy or tumor resection for benign tumors, with close monitoring of sex hormone levels postoperatively.
产生雄激素的类固醇细胞瘤卵巢肿瘤罕见，占卵巢肿瘤的不到 1%，可表现为不孕和快速男性化。本文讨论了一位 28 岁的女性病例，她不孕、多毛症和阴蒂肥大的病史已有 2 年，血清睾酮升高，左侧卵巢有肿块。她接受了卵巢切除术，病理显示为类固醇细胞瘤，无其他特定特征（NOS），无恶性特征。术后，患者的高雄激素症状随着睾酮在 6 个月内恢复正常而得到缓解，并且能够自然受孕。在有进行性高雄激素症状的育龄妇女中，应怀疑存在产生雄激素的肿瘤，包括卵巢来源的肿瘤。全面的检查，包括血浆激素水平和肿瘤组织学，可以做出准确的诊断和治疗。治疗应根据组织学和手术分期进行，考虑到未来的生育愿望。未完成生育的女性可以进行单侧卵巢切除术或良性肿瘤切除术，并在术后密切监测性激素水平。
