Department of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.
Graduate Medical Education, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.
J Pediatr Endocrinol Metab. 2022 May 23;35(6):821-825. doi: 10.1515/jpem-2022-0160. Print 2022 Jun 27.
Polycystic Ovary Syndrome (PCOS) is a common female endocrine disorder presenting as early as adolescence. Recent data suggest that Asians may be at increased risk. This study examines PCOS prevalence by race/ethnicity in a large, diverse population of adolescent females.
This retrospective study included 244,642 females (ages 13-17) with well-child visits during 2012-2018 in a Northern California healthcare system. Race/ethnicity and Asian ethnicity were classified using self-reported data. Body mass index was classified as healthy, overweight, and moderate/severe obesity. PCOS was determined by clinical diagnosis within one year of the visit.
The overall prevalence of PCOS was 0.7% and increased substantially with weight. Among those with obesity, PCOS prevalence was 4.2, 2.9, 2.4, 2.1% in Asian/Pacific Islander (PI), Hispanic/Latina, Non-Hispanic White, Black adolescents and 7.8, 6.7, 5.7, 3.4% in South Asian, Chinese, Filipina, Native Hawaiian/PI adolescents, respectively. Compared to White adolescents, Asian/PIs had two-fold higher risk of PCOS, and Hispanic/Latinas had 1.3-fold higher risk. Compared to Chinese adolescents, South Asians had 1.7-fold higher risk, while Native Hawaiian/PIs had half the risk.
The increased burden of diagnosed PCOS in Asian/PI and Hispanic/Latina adolescents, especially those with obesity, calls for further examination and clinical surveillance of at-risk populations.
多囊卵巢综合征（PCOS）是一种常见的女性内分泌疾病，早在青春期就会出现。最近的数据表明，亚洲人患该病的风险可能更高。本研究在一个大型、多样化的青春期女性人群中，按种族/族裔检查 PCOS 的患病率。
本回顾性研究纳入了 2012 年至 2018 年期间在加利福尼亚北部医疗保健系统接受常规健康检查的 244642 名 13-17 岁的女性。种族/族裔和亚裔种族是通过自我报告的数据进行分类的。体重指数分为健康、超重和中度/重度肥胖。PCOS 是根据就诊一年内的临床诊断确定的。
PCOS 的总体患病率为 0.7%，且随体重显著增加。在肥胖人群中，亚裔/太平洋岛民（PI）、西班牙裔/拉丁裔、非西班牙裔白人、黑人和南亚裔、华裔、菲律宾裔、夏威夷原住民/PI 青少年中 PCOS 的患病率分别为 4.2%、2.9%、2.4%、2.1%和 7.8%、6.7%、5.7%、3.4%。与白人青少年相比，亚裔/PI 患 PCOS 的风险高两倍，西班牙裔/拉丁裔患 PCOS 的风险高 1.3 倍。与华裔青少年相比，南亚裔青少年患 PCOS 的风险高 1.7 倍，而夏威夷原住民/PI 青少年患 PCOS 的风险低 50%。
亚裔/PI 和西班牙裔/拉丁裔青少年中诊断出的 PCOS 负担增加，尤其是肥胖者，这需要进一步检查和对高危人群进行临床监测。
