Latimer F R, AlSaadi A A, Robbins T O
J Neurooncol. 1987;4(3):287-91. doi: 10.1007/BF00150618.
Four medulloblastomas were studied cytogenetically with clinical follow-up of the patients. Three of these lesions were diploid and the patients manifested no recurrence at 40, 37 and 36 months respectively. The remaining tumor was aneuploid with 52 chromosomes and the patient expired of the medulloblastoma in 7 months. These findings are compared to nine previously reported karyotypes of primary medulloblastomas only two of which had clinical follow-up of the patients. On the basis of our results and these previously reported cases it appears that medulloblastomas with a diploid chromosomal pattern have a better prognosis than those with aneuploidy.
对4例髓母细胞瘤进行了细胞遗传学研究，并对患者进行了临床随访。其中3例病变为二倍体，患者分别在40、37和36个月时未出现复发。其余肿瘤为非整倍体，有52条染色体，患者在7个月时死于髓母细胞瘤。将这些结果与之前报道的9例原发性髓母细胞瘤的核型进行比较，其中只有2例对患者进行了临床随访。根据我们的结果和这些先前报道的病例，似乎具有二倍体染色体模式的髓母细胞瘤比非整倍体的预后更好。
