Human Development and Family Studies, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
Center for Family Research, University of Georgia, Athens, Georgia, USA.
Child Dev. 2022 Sep;93(5):1616-1624. doi: 10.1111/cdev.13795. Epub 2022 May 21.
The present study investigated developmental pathways that can contribute to chronic disease among rural African Americans. With a sample of 342 African American youth (59% female) from the southeastern United States followed for nearly two decades (2001-2019), we examined the prospective association between family poverty during adolescence (ages 11-18) and insulin resistance (IR) in young adulthood (ages 25-29) as well as underlying biological and psychosocial mechanisms. Results indicated family poverty during adolescence forecast higher levels of IR in young adulthood, with accelerated immune cell aging at age 20 partially mediating this association. Serial mediational models confirmed the hypothesized pathway linking family poverty, perceived life chances, cellular aging, and IR. Findings provide empirical support for theorized developmental precursors of chronic disease.
本研究调查了可能导致农村非裔美国人慢性疾病的发展途径。该研究在美国东南部对 342 名非裔美国青年（59%为女性）进行了近 20 年（2001-2019 年）的跟踪调查，研究了青少年期（11-18 岁）家庭贫困与青年期（25-29 岁）胰岛素抵抗之间的前瞻性关联，以及潜在的生物学和心理社会机制。结果表明，青少年期家庭贫困预示着青年期胰岛素抵抗水平较高，20 岁时免疫细胞衰老加速部分介导了这种关联。连续中介模型证实了假设的关联，即家庭贫困、感知生活机会、细胞衰老与胰岛素抵抗之间的联系。研究结果为慢性疾病的理论发展前体提供了实证支持。
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