Department of Spinal Surgery, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang, Hebei, 050051, People's Republic of China.
Hebei Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China.
Eur Spine J. 2022 Jul;31(7):1897-1905. doi: 10.1007/s00586-022-07259-y. Epub 2022 May 21.
It has not been determined which factors were related to multilevel lumbar disc degeneration (MLDD). The objective of this study was to determine the prevalence of MLDD among symptomatic patients using the magnetic resonance imaging method. The study also aimed to clarify the associations between MLDD and suspected risk factors through a multivariate model.
A total of 530 young and middle-aged patients, suffered from low back pain were retrospectively assessed by 2 independent observers, who used sagittal T2-weighted MR imaging. Subjects were divided into two groups, MLDD group and non-MLDD group, according to the number of degenerated discs. Demographic and radiological data included age, gender, weight, height, body mass index, smoking status, alcohol drinking, lumbar lordosis, presence of hypertension (HT), diabetes mellitus and anemia.
There were 309 men and 221 women with an average age of 37.5 ± 8.5 years. In general, 37.7% of patients were diagnosed with disc degeneration (DD) at more than two levels. Triple level DD was the most common pattern and was more prevalent in women (p <0.05). Using multivariate analyses, age (odds ratio [OR]: 1.14; 95% confidence interval [CI] 1.11-1.18; p <0.001), hypertension (OR: 2.67; 95% CI 1.38-5.16; p = 0.03) and anemia (OR: 3.84; 95% CI 2.03-7.28; p <0.001) were significantly associated with MLDD.
Despite the young age of this cohort, MLDD is common among patients with low back pain. A significant independent association exists between age, HT, anemia and multilevel disc degeneration in the lumbar region.
尚未确定哪些因素与多节段腰椎间盘退变（MLDD）有关。本研究的目的是使用磁共振成像（MRI）方法确定有症状患者中 MLDD 的患病率。该研究还旨在通过多变量模型阐明 MLDD 与可疑危险因素之间的关联。
回顾性评估了 530 名患有腰痛的年轻和中年患者，由 2 名独立观察者使用矢状 T2 加权 MRI 进行评估。根据退变椎间盘的数量，将患者分为 MLDD 组和非 MLDD 组。人口统计学和影像学数据包括年龄、性别、体重、身高、体重指数、吸烟状况、饮酒、腰椎前凸、高血压（HT）、糖尿病和贫血的存在。
共有 309 名男性和 221 名女性，平均年龄为 37.5 ± 8.5 岁。总体而言，37.7%的患者被诊断为两个以上水平的椎间盘退变（DD）。三级 DD 是最常见的模式，在女性中更为常见（p <0.05）。使用多变量分析，年龄（优势比 [OR]：1.14；95%置信区间 [CI] 1.11-1.18；p <0.001）、高血压（OR：2.67；95% CI 1.38-5.16；p = 0.03）和贫血（OR：3.84；95% CI 2.03-7.28；p <0.001）与 MLDD 显著相关。
尽管该队列年龄较轻，但腰痛患者中 MLDD 很常见。年龄、HT、贫血与腰椎多节段椎间盘退变之间存在显著的独立关联。
