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Development and tumorigenic potential of TP53: A therapeutic target for head and neck squamous cell carcinoma.

作者信息

Selvaraj Jayaraman, Yasothkumar Dinesh, Vishnu Priya Veeraraghavan, Raj A Thirumal, Babu Somasundaram Dinesh, Patil Shankargouda

机构信息

Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai 600077, India.

Department of Oral Pathology, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai 600077, India.

出版信息

Oral Oncol. 2022 Jul;130:105922. doi: 10.1016/j.oraloncology.2022.105922. Epub 2022 May 18.

DOI:10.1016/j.oraloncology.2022.105922
PMID:35596977
Abstract
摘要

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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.头颈部鳞状细胞癌中的TP53突变与生存情况
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Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck.SESN1、UHRF1BP1 和 miR-377-3p 的表达作为突变型 TP53 头颈部鳞状细胞癌的预后标志物。
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Identification of genomic mutations associated with clinical outcomes of induction chemotherapy in patients with head and neck squamous cell carcinoma.头颈部鳞状细胞癌患者诱导化疗临床结局相关基因组突变的鉴定
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The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.在头颈癌中，p53的肿瘤抑制能力依赖于非肌肉肌球蛋白IIA的功能。
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Targeted sequencing reveals TP53 as a potential diagnostic biomarker in the post-treatment surveillance of head and neck cancer.靶向测序揭示TP53作为头颈部癌治疗后监测中的潜在诊断生物标志物。
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Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis.可操作的体细胞突变对头颈部癌预后种族/民族差异的影响。
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