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替加环素和利奈唑胺对耐多药结核分枝杆菌的体外活性：微量肉汤稀释法和基因组学比较研究。

In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics.

机构信息

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

出版信息

Diagn Microbiol Infect Dis. 2022 Jul;103(3):115714. doi: 10.1016/j.diagmicrobio.2022.115714. Epub 2022 Apr 22.

DOI:10.1016/j.diagmicrobio.2022.115714
PMID:35596983
Abstract

The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD.

摘要

研究了替唑来德（TZD）对耐多药结核分枝杆菌分离株的作用。这可能是首次评估 TZD 对日本结核分枝杆菌分离株的 MIC 的研究。由于 TZD 的 MIC 明显低于 LZD（P<0.01），因此它被认为是一种更好、毒性更小的 LZD 替代品。

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