土贝母中的异喹啉生物碱具有潜在的抗肝癌和抗菌活性。
Isoquinoline alkaloids from the Corydalis tomentella with potential anti-hepatoma and antibacterial activities.
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
出版信息
Phytochemistry. 2022 Aug;200:113240. doi: 10.1016/j.phytochem.2022.113240. Epub 2022 May 19.
Six undescribed isoquinolines, including one rarely reported N-benzyl isoquinoline together with sixteen known ones were isolated from C. tomentella. Their planar structures and absolute configurations were elucidated by extensive analyses of UV, IR, NMR, HRESIMS, DP4+ probability analysis as well as ECD calculations. Biological evaluations revealed that 3,4-2H-tomentelline C (6) showed significant cytotoxicity (IC = 7.42 μM) against the HepG2 cell line while (1'R, 2'S)-coptichine B (3) exhibited stronger antibacterial activities.
从绒毛栝楼中分离得到了 6 个未被描述的异喹啉类化合物，包括一个罕见的 N-苄基异喹啉，以及 16 个已知的异喹啉类化合物。通过广泛的 UV、IR、NMR、HRESIMS、DP4+ 概率分析以及 ECD 计算等分析，确定了它们的平面结构和绝对构型。生物评价结果表明，3,4-2H-绒毛栝楼碱 C（6）对 HepG2 细胞系表现出显著的细胞毒性（IC=7.42μM），而（1'R, 2'S）-小檗红碱 B（3）则表现出更强的抗菌活性。
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