College of Textile and Clothing Engineering, Soochow University, Suzhou, 215123, China.
National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, 215123, China.
Macromol Biosci. 2022 Aug;22(8):e2200029. doi: 10.1002/mabi.202200029. Epub 2022 Jun 10.
Paracetamol is a safe and widely used antipyretic and analgesic drug, however, with the drawbacks of gastrointestinal first-pass effect and short intervals of administration. Transdermal drug delivery system can effectively avoid the liver metabolism caused by excess oral ingestion of paracetamol. Herein, a silk fabric-based medical dressing decorated by a thermo-responsive hydrogel for sustained release of paracetamol is proposed. Genipin as a bio-safe cross-linker is applied to assist gelation of a thermo-responsive hydrogel system coupled with chitosan and glycerol-phosphate disodium salt around body temperature (37 °C), as well as densifying the microporous gel to improve mechanical strength. The in situ sol-gel transition enabled hydrogel well penetrate and coat the silk fabric, forming a hierarchical hydrogel structure capable of prolonging the sustained release of drug to 12 h, twice as long as a blank fabric. The silk fabric with a thin gel coating maintains a good water vapor transmission rate, compatible for skin contact application. The drug release properties can be tuned by regulating the genipin content and fabric braiding structure. The silk fabric dressing exhibits temperature-dependent instant release behavior within the first 2 h. The sustained release mechanism of paracetamol well matches with the Korsmeyer-Peppas model in a non-Fickian diffusion.
对乙酰氨基酚是一种安全且广泛使用的解热镇痛药，但是存在胃肠道首过效应和给药间隔短的缺点。透皮给药系统可以有效避免因过量口服对乙酰氨基酚而引起的肝脏代谢。本文提出了一种基于丝织物的医用敷料，该敷料由温敏水凝胶修饰，可实现对乙酰氨基酚的持续释放。本文使用生物安全的交联剂京尼平辅助温敏水凝胶体系（由壳聚糖和甘油磷酸二钠组成）在体温（37°C）下发生凝胶化，并使微多孔凝胶致密化，从而提高力学强度。原位溶胶-凝胶转变使水凝胶能够很好地渗透和包裹丝织物，形成一种分级水凝胶结构，能够将药物的持续释放时间延长至 12 小时，是空白织物的两倍。具有薄凝胶涂层的丝织物保持良好的水蒸气透过率，适合与皮肤接触应用。药物释放性能可以通过调节京尼平含量和织物编织结构来进行调控。丝织物敷料在最初的 2 小时内表现出温度依赖性的即时释放行为。对乙酰氨基酚的持续释放机制符合非菲克扩散的 Korsmeyer-Peppas 模型。
