Myers T F, Patrinos M E, Muraskas J, Caldwell C C, Lambert G H, Anderson C L
J Pediatr. 1987 Apr;110(4):611-6. doi: 10.1016/s0022-3476(87)80562-0.
A method for obtaining reproducible Doppler cerebral blood flow velocity (CBFV) measurements over several hours, utilizing a probe fixation technique and an on-line system for making beat-to-beat area under the curve (AUC) measurements, is described. Thirty heartbeat samples were collected at three time intervals over 3 hours in a group of 22 healthy preterm infants. The stability of the AUC measurements despite changes in behavioral state was demonstrated by randomized block ANOVA. The sampling error was +/- 6.92%, with 95% confidence intervals of +/- 13.1%. By facilitating reproducible serial measurements of CBFV, this trend monitoring technique encourages a dynamic view of cerebrovascular control, and may be used to probe central nervous system autoregulatory pathophysiology and to evaluate the effects of therapeutic interventions.
本文描述了一种在数小时内获得可重复的多普勒脑血流速度（CBFV）测量值的方法，该方法利用了探头固定技术和用于逐搏测量曲线下面积（AUC）的在线系统。在一组22名健康早产儿中，在3小时内以三个时间间隔采集了30个心跳样本。通过随机区组方差分析证明了尽管行为状态发生变化，AUC测量值仍具有稳定性。抽样误差为±6.92%，95%置信区间为±13.1%。通过促进CBFV的可重复连续测量，这种趋势监测技术有助于对脑血管控制形成动态认识，并可用于探究中枢神经系统自动调节病理生理学以及评估治疗干预的效果。
