Anthony M Y, Evans D H, Levene M I
Department of Paediatrics, University of Leeds, General Infirmary.
Arch Dis Child. 1991 Jan;66(1 Spec No):12-6. doi: 10.1136/adc.66.1_spec_no.12.
Because little is known about spontaneous changes in cerebral blood flow in neonates, a newly developed online Doppler technique was used to insonate continuously the middle cerebral arteries of a group of sick (n = 20) and full term healthy (n = 16) newborn infants for a period of one minute. A total of 290 recordings of epochs each lasting one minute were analysed, and pronounced regular, cyclical variations were seen in the velocity traces of these infants. The cycles occurred 1.5-5 times/minute and were present for at least one epoch in all 20 of the sick infants and in 15 of the 16 healthy mature neonates. Simultaneous recordings of the systemic blood pressure in the sick infants rarely showed the same cyclical variations. The cyclical variation is different from the beat to beat variability seen in the waveforms previously described, and is an additional factor to account for the wide variation in 'normal' velocity recordings obtained when Doppler ultrasound is measured over a short period of time.
由于对新生儿脑血流的自发变化了解甚少，因此采用一种新开发的在线多普勒技术，对一组患病新生儿（n = 20）和足月健康新生儿（n = 16）的大脑中动脉进行了一分钟的连续超声检查。共分析了290段持续一分钟的记录，结果发现这些婴儿的速度轨迹存在明显的规则性、周期性变化。这些周期每分钟出现1.5 - 5次，所有20名患病婴儿以及16名健康成熟新生儿中的15名至少有一个记录段出现了这种周期变化。对患病婴儿的体循环血压进行同步记录时，很少显示出相同的周期性变化。这种周期性变化不同于先前描述的波形中逐搏变化，是解释在短时间内用多普勒超声测量时“正常”速度记录存在广泛差异的一个额外因素。
