甘露糖结合凝集素水平及其与红斑狼疮疾病严重程度的关系：印度报告。

Mannose Binding Lectin Levels and its Association with Systemic Lupus Erythematosus Disease Severity: An Indian Report.

机构信息

Department of Innate Immunity, National Institute for Research in Reproductive Health (ICMR), Mumbai, Maharashtra.

Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, King Edward Memorial Hospital, Mumbai, Maharashtra.

出版信息

J Assoc Physicians India. 2022 May;70(5):11-12.

PMID:35598129

Abstract

BACKGROUND

Dysregulated serum levels of Mannan binding lectin (MBL) has a probable role in Systemic Lupus Erythematosus (SLE) pathogenesis.

OBJECTIVE

To evaluate the association between serum MBL levels in SLE patients from western India with the severity of disease Methods: SLE patients (n=70) from Western India were included. Based on MBL levels, patients were classified into four categories, viz. low (<100 ng/ml), mild (100-500 ng/ml), moderate (500-1000 ng/ml) and high (>1000 ng/ml). Correlation of serum MBL levels with disease severity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). MBL levels and circulating immune complex levels were detected by ELISA. C3, C4 and CRP levels were detected by nephelometer.

RESULTS

Serum MBL levels of SLE patients (1954 ± 202.4 ng/ml) was lower than that of healthy controls (2388 ± 205.0 ng/ ml). There was no significant correlation between MBL levels with severity of SLE on the basis of ACR criteria and SLEDAI scores (p> 0.05). No significant difference was observed among MBL levels and SLE patients with (1847 ± 246.7) or without (1900 ± 246.8) Lupus Nephritis. SLE patients without infections (n= 33) had low MBL levels (1700 ± 301.0 ng/ ml) as compared with SLE patients with infection (n= 37) (2189 ± 284.6 ng/ ml) (p=0.30) Conclusion: Present study indicated that low MBL levels were not associated with disease severity, haematological manifestations and infections among SLE patients from Western India.

摘要

背景

甘露聚糖结合凝集素（MBL）的血清水平失调可能在系统性红斑狼疮（SLE）发病机制中起作用。

目的

评估来自印度西部的 SLE 患者的血清 MBL 水平与疾病严重程度之间的关联。

方法

纳入来自印度西部的 SLE 患者（n=70）。根据 MBL 水平，患者分为四组，即低（<100ng/ml）、轻度（100-500ng/ml）、中度（500-1000ng/ml）和高（>1000ng/ml）。使用系统性红斑狼疮疾病活动指数（SLEDAI）评估血清 MBL 水平与疾病严重程度的相关性。通过 ELISA 检测血清 MBL 水平和循环免疫复合物水平。通过比浊法检测 C3、C4 和 CRP 水平。

结果

SLE 患者的血清 MBL 水平（1954±202.4ng/ml）低于健康对照组（2388±205.0ng/ml）。根据 ACR 标准和 SLEDAI 评分，MBL 水平与 SLE 的严重程度之间无显著相关性（p>0.05）。在有（1847±246.7）或无（1900±246.8）狼疮肾炎的 SLE 患者中，MBL 水平之间无显著差异。无感染的 SLE 患者（n=33）的 MBL 水平较低（1700±301.0ng/ml），而有感染的 SLE 患者（n=37）的 MBL 水平较高（2189±284.6ng/ml）（p=0.30）。