通过下托区进行协调震荡、抗噪信息分布。

Oscillation-coordinated, noise-resistant information distribution via the subiculum.

机构信息

Department of Physiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Osaka 545-8585, Japan; Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka, Osaka 545-8585, Japan.

Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka, Osaka 545-8585, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo 153-8902, Japan; Komaba Institute for Science, The University of Tokyo, Meguro, Tokyo 153-8902, Japan; PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan.

出版信息

Curr Opin Neurobiol. 2022 Aug;75:102556. doi: 10.1016/j.conb.2022.102556. Epub 2022 May 19.

DOI:10.1016/j.conb.2022.102556

PMID:35598550

Abstract

The hippocampus processes information associated with spatial navigation. The subiculum receives input from the hippocampus CA1 and projects to various cortical and subcortical regions. Thus, the subiculum is uniquely positioned to distribute hippocampal information to a range of brain areas. Subicular neurons fire at higher rates than CA1 neurons and exhibit similarly or more accurately decodable representations of place, speed, and trajectory. These representations are more noise-resistant and advantageous for long-range information transfer. Subicular neurons selectively or uniformly distribute information to target areas, depending on the information type. Theta oscillations and sharp-wave ripples control information broadcasting in a pathway-specific manner. Thus, the subiculum routes accurately decodable, noise-resistant, navigation-associated information to downstream regions.

摘要

海马体处理与空间导航相关的信息。下托接收来自海马体 CA1 的输入，并投射到各种皮质和皮质下区域。因此，下托的位置独特，能够将海马体的信息分布到一系列脑区。下托神经元的放电频率高于 CA1 神经元，并且对位置、速度和轨迹具有类似或更准确的可解码表示。这些表示对噪声更具抗性，并且有利于长距离信息传递。下托神经元根据信息类型有选择地或均匀地将信息分配到目标区域。θ 振荡和尖波涟漪以特定于通路的方式控制信息广播。因此，下托将准确可解码、抗噪、与导航相关的信息路由到下游区域。