Association for Cardiac Research, Rome, Italy.
Association for Cardiac Research, Rome, Italy; EA 4650, Signalisation, électrophysiologie et imagerie des lésions d'ischémie reperfusion myocardique, UNICAEN, 14000 Caen, France.
Nutr Metab Cardiovasc Dis. 2022 Aug;32(8):1819-1829. doi: 10.1016/j.numecd.2022.04.010. Epub 2022 Apr 19.
To test a dietary score produced from individual data of middle-aged-men enrolled in 1960 based on an a-posteriori approach and to study its association with some specific causes of death during 61 years until their practical extinction.
In 1960 the Italian Rural Areas of the Seven Countries of Cardiovascular Diseases were enrolled and 1712 men aged 40-59 were examined with measurement of several risk factors and the collection of dietary history. Using 18 food groups a factor score was obtained from a Principal Component Analysis, that was divided into three classes, arbitrarily called non-Mediterranean, Intermediate and Mediterranean diets. Follow-up for mortality was extended for 61 years and dietary habits were related to several causes of death. There were 1708 deaths (99.8%) and Cox proportional hazards models, adjusted for five major risk factors, showed a significant protective effect of Mediterranean diet for coronary heart disease [Hazard Ratio (HR) = 0.67], cancer other than lung (0.74) and other causes, as from an operational definition (0.71), covering overall about 60% of all deaths. HR for all-cause mortality was of 0.85. In parallel, Kaplan-Meier curves provided significant p of log rank test for the same end-points (<0.0001, 0.0002, 0.0002 and < 0.0001, respectively). On the other hand, stroke, heart diseases of uncertain etiology, lung cancer, chronic bronchitis, unknown causes were not associated to dietary habits.
In a 61-year follow-up of middle-aged men, the Mediterranean diet was beneficial for a large part of the causes of death and for total mortality.
基于后验方法，检验根据 1960 年中年男性个体数据生成的膳食评分，并研究其与 61 年内某些特定死亡原因的关系，直至这些男性实际灭绝。
1960 年，意大利农村地区的七国心血管疾病研究纳入了 1712 名 40-59 岁的男性，对其进行了多项风险因素检测和饮食史收集。使用 18 种食物组，通过主成分分析获得了一个因子得分，该得分分为三类，任意命名为非地中海、中间和地中海饮食。对死亡率的随访时间延长至 61 年，并将饮食习惯与多种死亡原因相关联。共有 1708 人死亡（99.8%），经 Cox 比例风险模型校正了 5 个主要风险因素后，发现地中海饮食对冠心病（危险比 [HR] = 0.67）、肺癌以外的癌症（0.74）和其他原因（从操作定义来看，0.71）具有显著的保护作用，涵盖了约 60%的所有死亡。所有原因死亡率的 HR 为 0.85。同时，Kaplan-Meier 曲线为相同的终点提供了显著的对数秩检验 p 值（<0.0001、0.0002、0.0002 和 <0.0001，分别）。另一方面，中风、病因不明的心脏病、肺癌、慢性支气管炎、未知原因与饮食习惯无关。
在对中年男性进行的 61 年随访中，地中海饮食对大部分死亡原因和总死亡率有益。
