Paveenbampen C, Lamontanaro D, Moody J, Zarembo J, Rehm C
J Pharm Sci. 1986 Dec;75(12):1192-4. doi: 10.1002/jps.2600751217.
A reversed-phase high-performance liquid chromatographic method is described for a stability-indicating assay of folic acid in multivitamin preparations. This method shows excellent recovery and precision characteristics, allows the determination of folic acid to levels of 0.1 microgram/mL, is simple to execute, and is suitable for high volume routine work. A good correlation was demonstrated between the HPLC method and the currently used bioassay.
描述了一种反相高效液相色谱法，用于多种维生素制剂中叶酸的稳定性指示测定。该方法具有出色的回收率和精密度特性，可将叶酸测定至0.1微克/毫升的水平，操作简单，适用于大量的常规工作。高效液相色谱法与目前使用的生物测定法之间显示出良好的相关性。
