Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Acta Obstet Gynecol Scand. 2022 Jul;101(7):719-727. doi: 10.1111/aogs.14380. Epub 2022 May 22.
The association between intrahepatic cholestasis of pregnancy (ICP) and maternal lipid metabolism remains unknown. This systematic review and meta-analysis aimed to evaluate the association between ICP and maternal lipid metabolism.
We systematically searched Medline, Embase and the Cochrane Library (up to December 11, 2021) to identify relevant studies that investigated ICP and maternal plasma lipid concentrations. The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated using random-effects models. A subgroup analysis was conducted to identify the potential sources of heterogeneity. Potential publication bias was tested using funnel plots and the Egger's and Begg's tests. This meta-analysis was registered with PROSPERO (CRD42021293783).
Eleven studies were included in this qualitative analysis. A random-effects meta-analysis of data from the final included nine studies (n = 786 participants) showed a significant association between ICP and maternal dyslipidemia, with elevated levels of triglycerides (WMD, 0.67 mmol/L; 95% CI 0.39-0.95; P < 0.001), total cholesterol (WMD, 1.08 mmol/L; 95% CI 0.58-1.58; P < 0.001), low-density lipoprotein cholesterol (WMD, 1.08 mmol/L; 95% CI 0.53-1.64; P < 0.001), and reduced high-density lipoprotein cholesterol level (WMD, -0.38 mmol/L; 95% CI -0.53 to -0.23; P < 0.001) vs normal pregnancies.
The present study's findings support an association between ICP and maternal dyslipidemia. ICP pregnancies have dysregulated lipid metabolism vs normal pregnancies.
妊娠肝内胆汁淤积症（ICP）与母体脂质代谢之间的关系尚不清楚。本系统评价和荟萃分析旨在评估 ICP 与母体脂质代谢之间的关系。
我们系统地检索了 Medline、Embase 和 Cochrane 图书馆（截至 2021 年 12 月 11 日），以确定调查 ICP 和母体血浆脂质浓度的相关研究。使用随机效应模型计算加权均数差（WMD）和 95%置信区间（CI）。进行亚组分析以确定潜在的异质性来源。使用漏斗图和 Egger 及 Begg 检验测试潜在的发表偏倚。本荟萃分析已在 PROSPERO（CRD42021293783）上注册。
本定性分析纳入了 11 项研究。最终纳入的 9 项研究（n=786 名参与者）的数据进行随机效应荟萃分析显示，ICP 与母体血脂异常存在显著相关性，表现为甘油三酯水平升高（WMD，0.67mmol/L；95%CI，0.39-0.95；P<0.001）、总胆固醇（WMD，1.08mmol/L；95%CI，0.58-1.58；P<0.001）、低密度脂蛋白胆固醇（WMD，1.08mmol/L；95%CI，0.53-1.64；P<0.001）升高和高密度脂蛋白胆固醇水平降低（WMD，-0.38mmol/L；95%CI，-0.53 至-0.23；P<0.001）。
本研究结果支持 ICP 与母体血脂异常之间存在关联。ICP 妊娠与正常妊娠相比，脂质代谢失调。
