• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SLC8A1 反义 RNA1 通过 FUS RNA 结合蛋白 (FUS)/NUMB 样内吞衔接蛋白 (Numbl) 轴抑制甲状腺乳头状癌恶性进展。

SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis.

机构信息

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China.

Department of Gastroenterology, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China.

出版信息

Bioengineered. 2022 May;13(5):12572-12582. doi: 10.1080/21655979.2022.2073125.

DOI:10.1080/21655979.2022.2073125
PMID:35599603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9275960/
Abstract

Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies and is associated with severe morbidity and high mortality. This study aimed to explore the role of long non-coding RNA (lncRNA) SLC8A1 antisense RNA 1 (SLC8A1-AS1) in the pathogenesis of PTC. In this study, we explored the function of SLC8A1-AS1 in PTC progression. We observed that the expression of SLC8A1-AS1 was downregulated in clinical PTC samples and PTC cell lines compared to that in normal controls. Cell counting kit (CCK)-8 assays demonstrated that the overexpression of SLC8A1-AS1 significantly reduced the proliferation of PTC cells. Consistently, apoptosis of PTC cells was enhanced by SLC8A1-AS1 overexpression. SLC8A1-AS1 overexpression attenuated the invasion and migration of PTC cells. Mechanistically, SLC8A1-AS1 maintained NUMB like endocytic adaptor protein (Numbl) mRNA stability by interacting with FUS RNA Binding Protein (FUS) in PTC cells. Depletion of Numbl reversed the inhibitory effect of SLC8A1-AS1 overexpression on PTC. Thus, we concluded that SLC8A1-AS1 suppresses PTC progression via the FUS/Numbl axis. Our findings provide novel insights into the mechanism underlying SLC8A1-AS1 attenuation of the malignant development of PTC, improving our understanding of the association between lncRNAs and PTC. SLC8A1-AS1 and FUS may be potential targets for PTC treatment.

摘要

甲状腺乳头状癌（PTC）是最常见的内分泌恶性肿瘤之一，与严重的发病率和高死亡率相关。本研究旨在探讨长链非编码 RNA（lncRNA）SLC8A1 反义 RNA 1（SLC8A1-AS1）在 PTC 发病机制中的作用。在本研究中，我们探讨了 SLC8A1-AS1 在 PTC 进展中的功能。我们观察到，与正常对照相比，临床 PTC 样本和 PTC 细胞系中 SLC8A1-AS1 的表达下调。细胞计数试剂盒（CCK）-8 测定表明，SLC8A1-AS1 的过表达显著降低了 PTC 细胞的增殖。一致地，SLC8A1-AS1 的过表达增强了 PTC 细胞的凋亡。SLC8A1-AS1 的过表达减弱了 PTC 细胞的侵袭和迁移。机制上，SLC8A1-AS1 通过与 FUS RNA 结合蛋白（FUS）相互作用维持 PTC 细胞中 NUMB 样内吞衔接蛋白（Numbl）mRNA 的稳定性。Numbl 的耗竭逆转了 SLC8A1-AS1 过表达对 PTC 的抑制作用。因此，我们得出结论，SLC8A1-AS1 通过 FUS/Numbl 轴抑制 PTC 的进展。我们的研究结果为 SLC8A1-AS1 减弱 PTC 恶性发展的机制提供了新的见解，提高了我们对 lncRNA 与 PTC 之间关联的理解。SLC8A1-AS1 和 FUS 可能是 PTC 治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/d67c7984a292/KBIE_A_2073125_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/483e6027d4fd/KBIE_A_2073125_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/d0c7e8e171d5/KBIE_A_2073125_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/5e62397700fa/KBIE_A_2073125_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/cd4dece01c0e/KBIE_A_2073125_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/ac2f59538a4b/KBIE_A_2073125_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/8bc4fee1f765/KBIE_A_2073125_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/d67c7984a292/KBIE_A_2073125_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/483e6027d4fd/KBIE_A_2073125_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/d0c7e8e171d5/KBIE_A_2073125_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/5e62397700fa/KBIE_A_2073125_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/cd4dece01c0e/KBIE_A_2073125_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/ac2f59538a4b/KBIE_A_2073125_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/8bc4fee1f765/KBIE_A_2073125_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ec/9275960/d67c7984a292/KBIE_A_2073125_F0006_OC.jpg

相似文献

1
SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis.SLC8A1 反义 RNA1 通过 FUS RNA 结合蛋白 (FUS)/NUMB 样内吞衔接蛋白 (Numbl) 轴抑制甲状腺乳头状癌恶性进展。
Bioengineered. 2022 May;13(5):12572-12582. doi: 10.1080/21655979.2022.2073125.
2
Silencing long non-coding RNAs nicotinamide nucleotide transhydrogenase antisense RNA 1 inhibited papillary thyroid cancer cell proliferation, migration and invasion and promoted apoptosis via targeting miR-199a-5p.沉默长链非编码 RNA 烟酰胺核苷酸转氢酶反义 RNA 1 通过靶向 miR-199a-5p 抑制甲状腺乳头状癌细胞增殖、迁移和侵袭并促进细胞凋亡。
Endocr J. 2021 May 28;68(5):583-597. doi: 10.1507/endocrj.EJ20-0353. Epub 2021 Mar 20.
3
Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p/ZNRF2 axis.长链非编码 RNA TTN-AS1 通过调节 miR-153-3p/ZNRF2 轴促进甲状腺乳头状癌的发生。
J Gene Med. 2019 May;21(5):e3083. doi: 10.1002/jgm.3083. Epub 2019 Mar 25.
4
RNF185 antisense RNA 1 (RNF185-AS1) promotes proliferation, migration, and invasion in papillary thyroid carcinoma.环状 RNA1（RNF185-AS1）反义 RNA 促进甲状腺乳头状癌的增殖、迁移和侵袭。
Anticancer Drugs. 2022 Jul 1;33(6):595-606. doi: 10.1097/CAD.0000000000001295. Epub 2022 Mar 23.
5
Long noncoding RNA ABHD11-AS1 functions as a competing endogenous RNA to regulate papillary thyroid cancer progression by miR-199a-5p/SLC1A5 axis.长链非编码 RNA ABHD11-AS1 通过 miR-199a-5p/SLC1A5 轴作为竞争性内源性 RNA 调节甲状腺乳头状癌的进展。
Cell Death Dis. 2019 Aug 14;10(8):620. doi: 10.1038/s41419-019-1850-4.
6
LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein.长链非编码 RNA SOCS2-AS1 通过使 p53 蛋白不稳定促进甲状腺乳头状癌的进展。
Biochem Biophys Res Commun. 2023 Aug 20;669:95-102. doi: 10.1016/j.bbrc.2023.05.080. Epub 2023 May 22.
7
LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR-20a-5p/RBM38 axis.长链非编码 RNA CALML3-AS1 通过海绵吸附 miR-20a-5p/RBM38 轴抑制甲状腺乳头状癌细胞的进展。
BMC Cancer. 2022 Mar 29;22(1):344. doi: 10.1186/s12885-022-09360-3.
8
Overexpression of ST7-AS1 Enhances Apoptosis and Inhibits Proliferation of Papillary Thyroid Carcinoma Cells Via microRNA-181b-5p-Dependent Inhibition Tripartite Motif Containing 3.ST7-AS1的过表达通过微小RNA-181b-5p依赖性抑制含三联体基序蛋白3增强甲状腺乳头状癌细胞的凋亡并抑制其增殖。
Mol Biotechnol. 2023 Mar;65(3):477-490. doi: 10.1007/s12033-022-00536-7. Epub 2022 Aug 27.
9
Overexpression of serum lncRNA-ABHD11-AS1 as poor prognosis of patients with papillary thyroid carcinoma.血清 lncRNA-ABHD11-AS1 过表达与甲状腺乳头状癌患者预后不良相关。
Exp Mol Pathol. 2021 Aug;121:104658. doi: 10.1016/j.yexmp.2021.104658. Epub 2021 Jun 6.
10
Long non-coding RNA ASMTL-AS1 inhibits tumor growth and glycolysis by regulating the miR-93-3p/miR-660/FOXO1 axis in papillary thyroid carcinoma.长链非编码 RNA ASMTL-AS1 通过调控 miR-93-3p/miR-660/FOXO1 轴抑制甲状腺乳头状癌肿瘤生长和糖酵解。
Life Sci. 2020 Mar 1;244:117298. doi: 10.1016/j.lfs.2020.117298. Epub 2020 Jan 14.

引用本文的文献

1
Application and clinical translational value of a predictive model based on N-methylguanosine-related long non-coding RNAs in cervical squamous cell carcinoma.基于N-甲基鸟苷相关长链非编码RNA的预测模型在宫颈鳞状细胞癌中的应用及临床转化价值
Oncol Lett. 2025 May 14;30(1):341. doi: 10.3892/ol.2025.15087. eCollection 2025 Jul.
2
A narrative review of papillary thyroid carcinoma-related long non-coding RNAs and their relevance to malignant tumors.甲状腺乳头状癌相关长链非编码RNA及其与恶性肿瘤相关性的叙述性综述
Transl Cancer Res. 2025 Mar 30;14(3):2125-2149. doi: 10.21037/tcr-24-1038. Epub 2025 Mar 27.
3
Numb and NumbL inhibit melanoma tumor growth by influencing the immune microenvironment.

本文引用的文献

1
Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer.长链非编码 RNA ADAMTS9-AS1 通过靶向 microRNA-587/溶质载体家族 7 成员 11 轴抑制上皮性卵巢癌中的铁死亡。
Bioengineered. 2022 Apr;13(4):8226-8239. doi: 10.1080/21655979.2022.2049470.
2
Long non-coding RNA FAM230B is a novel prognostic and diagnostic biomarker for lung adenocarcinoma.长非编码 RNA FAM230B 是肺腺癌的一种新型预后和诊断生物标志物。
Bioengineered. 2022 Mar;13(3):7919-7925. doi: 10.1080/21655979.2022.2034568.
3
LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway.
麻木蛋白和麻木蛋白 L 通过影响免疫微环境抑制黑色素瘤肿瘤生长。
BMC Cancer. 2024 Nov 18;24(1):1419. doi: 10.1186/s12885-024-13191-9.
4
CircRNA_SLC8A1 alleviates hypertrophic scar progression by mediating the Nrf2-ARE pathway.环状 RNA_SLC8A1 通过介导 Nrf2-ARE 通路缓解增生性瘢痕进展。
Mol Biol Rep. 2024 Oct 18;51(1):1067. doi: 10.1007/s11033-024-10018-5.
5
Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation.转录组分析揭示了长非编码 RNA、可变剪接和可变多聚腺苷酸化对脂肪生成的调控。
Sci Rep. 2024 Jul 23;14(1):16964. doi: 10.1038/s41598-024-67648-9.
6
Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS.PRC2和FUS结合的核微小RNA、长链非编码RNA和环状RNA在癌症中的意义
Cancers (Basel). 2024 Feb 21;16(5):868. doi: 10.3390/cancers16050868.
7
Identification of a novel lymphangiogenesis signature associated with immune cell infiltration in colorectal cancer based on bioinformatics analysis.基于生物信息学分析鉴定与结直肠癌免疫细胞浸润相关的新型淋巴管生成特征。
BMC Med Genomics. 2024 Jan 2;17(1):2. doi: 10.1186/s12920-023-01781-8.
8
HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA as an Oncological Biomarker and Therapeutic Target in Human Malignancies.HOXC簇反义RNA 3，一种新型长链非编码RNA，作为人类恶性肿瘤中的肿瘤生物标志物和治疗靶点。
Onco Targets Ther. 2023 Oct 24;16:849-865. doi: 10.2147/OTT.S425523. eCollection 2023.
9
Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors.全面泛癌分析 NUMB 和 NUMBL 在人类肿瘤中的表达谱和预后意义。
Medicine (Baltimore). 2023 Sep 1;102(35):e34717. doi: 10.1097/MD.0000000000034717.
10
CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.环状锌指蛋白 367 通过与 FUS 相互作用维持 CRY2 mRNA 稳定性，促进破骨细胞分化和骨质疏松症。
J Orthop Surg Res. 2023 Jul 11;18(1):492. doi: 10.1186/s13018-023-03955-7.
LEM 结构域包含蛋白 1 通过 p53 和 mTORC1 信号通路促进胰腺癌的生长和转移。
Bioengineered. 2022 Mar;13(3):7771-7784. doi: 10.1080/21655979.2022.2047404.
4
Long non-coding RNA CATIP antisense RNA 1 (lncRNA CATIP-AS1) downregulation contributes to the progression and metastasis of thyroid cancer via epithelial-mesenchymal transition (EMT) pathway.长链非编码 RNA CATIP 反义 RNA 1（lncRNA CATIP-AS1）下调通过上皮-间充质转化（EMT）途径促进甲状腺癌的进展和转移。
Bioengineered. 2022 Mar;13(3):7592-7606. doi: 10.1080/21655979.2022.2047400.
5
The anti-cancer role of microRNA-143 in papillary thyroid carcinoma by targeting high mobility group AT-hook 2.microRNA-143 通过靶向高迁移率族 AT 钩蛋白 2 在甲状腺乳头状癌中的抗癌作用。
Bioengineered. 2022 Mar;13(3):6629-6640. doi: 10.1080/21655979.2022.2044277.
6
Knockdown of nuclear receptor binding SET domain-containing protein 1 (NSD1) inhibits proliferation and facilitates apoptosis in paclitaxel-resistant breast cancer cells via inactivating the Wnt/β-catenin signaling pathway.敲低核受体结合 SET 域蛋白 1（NSD1）通过使 Wnt/β-连环蛋白信号通路失活来抑制紫杉醇耐药乳腺癌细胞的增殖并促进其凋亡。
Bioengineered. 2022 Feb;13(2):3526-3536. doi: 10.1080/21655979.2021.2018973.
7
CircRNA ZNF609 promotes the growth and metastasis of thyroid cancer and by downregulating miR-514a-5p.环状 RNA ZNF609 通过下调 miR-514a-5p 促进甲状腺癌的生长和转移。
Bioengineered. 2022 Feb;13(2):4372-4384. doi: 10.1080/21655979.2022.2033015.
8
The long noncoding RNA noncoding RNA activated by DNA damage (NORAD)-microRNA-496-Interleukin-33 axis affects carcinoma-associated fibroblasts-mediated gastric cancer development.长链非编码 RNA 受 DNA 损伤激活（NORAD）-微小 RNA-496-白细胞介素-33 轴影响癌相关成纤维细胞介导的胃癌发展。
Bioengineered. 2021 Dec;12(2):11738-11755. doi: 10.1080/21655979.2021.2009412.
9
LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer.长链非编码 RNA SNHG1 通过表观遗传沉默 miR-381 促进乳腺癌的肿瘤进展和顺铂耐药性。
Bioengineered. 2021 Dec;12(2):9239-9250. doi: 10.1080/21655979.2021.1996305.
10
ETS like-1 protein ELK1-induced lncRNA LINC01638 accelerates the progression of papillary thyroid cancer by regulating Axin2 through Wnt/β-catenin signaling pathway.ETS 样蛋白 ELK1 诱导的长链非编码 RNA LINC01638 通过 Wnt/β-连环蛋白信号通路调节 Axin2 加速甲状腺乳头状癌的进展。
Bioengineered. 2021 Dec;12(1):3873-3885. doi: 10.1080/21655979.2021.1935404.