Malaisse W J, Boschero A C, Kawazu S, Hutton J C
Pflugers Arch. 1978 Mar 20;373(3):237-42. doi: 10.1007/BF00580830.
The effect of glucose upon the handling of K+ by islets of Langerhans removed from normal rats was investigated by measuring both the net uptake of 86Rb+ and its efflux from prelabelled islets. The inflow of K+ into islet cells is mediated, in part at least, by an ouabain-sensitive pump. Glucose fails to affect the inflow rate of K+, but it apparently decreases the permeability of islet cells plasma membrane to effuent K+. The glucose-induced change in permeability is a rapid and rapidly reversible phenomenon. Under steady-state conditions, it leads to an increase in the islet cells K+ pool and a decrease of its fractional turnover rate.
通过测量从正常大鼠分离的胰岛对⁸⁶Rb⁺的净摄取及其从预先标记的胰岛中的流出量，研究了葡萄糖对胰岛处理钾离子（K⁺）的影响。钾离子流入胰岛细胞至少部分是由哇巴因敏感泵介导的。葡萄糖不会影响钾离子的流入速率，但它显然会降低胰岛细胞质膜对流出钾离子的通透性。葡萄糖诱导的通透性变化是一种快速且可逆的现象。在稳态条件下，它会导致胰岛细胞钾离子池增加，其分数周转率降低。
