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OK-432对一名患有18三体综合征的低体重儿术后乳糜胸的治疗效果

The usefulness of OK-432 for the treatment of postoperative chylothorax in a low-birth-weight infant with trisomy 18.

作者信息

Takahashi Yoshiaki, Kinoshita Yoshiaki, Kobayashi Takashi, Arai Yuhki, Ohyama Toshiyuki, Yokota Naoki, Saito Koichi, Sugai Yu, Takano Shoichi

机构信息

Department of Pediatric Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.

出版信息

Clin Case Rep. 2022 May 20;10(5):e05844. doi: 10.1002/ccr3.5844. eCollection 2022 May.

DOI:10.1002/ccr3.5844
PMID:35600015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9122797/
Abstract

Chylothorax is a rare but life-threatening condition in neonates. We herein report the successful use of OK-432 for a low-birth-weight infant with trisomy 18 who developed refractory chylothorax after thoracic surgery. Increasing the concentration of OK-432 seems useful in cases with a lot of pleural effusion.

摘要

乳糜胸在新生儿中是一种罕见但危及生命的病症。我们在此报告成功使用溶链菌制剂（OK-432）治疗一名患有18三体综合征的低体重婴儿，该婴儿在胸外科手术后出现难治性乳糜胸。对于胸腔积液较多的病例，增加OK-432的浓度似乎有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/ed52c1a0a4c3/CCR3-10-e05844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/9858e64e2689/CCR3-10-e05844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/eacbbbb4c6e6/CCR3-10-e05844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/ed52c1a0a4c3/CCR3-10-e05844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/9858e64e2689/CCR3-10-e05844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/eacbbbb4c6e6/CCR3-10-e05844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4603/9122797/ed52c1a0a4c3/CCR3-10-e05844-g001.jpg

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Clin Case Rep. 2022 May 20;10(5):e05844. doi: 10.1002/ccr3.5844. eCollection 2022 May.
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本文引用的文献

1
Management of refractory chylothorax in the neonatal intensive care unit: A 22-year experience.新生儿重症监护病房难治性乳糜胸的管理：22 年经验。
Pediatr Int. 2022 Jan;64(1):e15043. doi: 10.1111/ped.15043.
2
Should Newborns with Refractory Chylothorax Be Tried on Higher Dose of Octreotide?对于难治性乳糜胸的新生儿，是否应该尝试更高剂量的奥曲肽？
Neonatology. 2021;118(1):122-126. doi: 10.1159/000512461. Epub 2021 Jan 25.
3
Comparison of postoperative chylothorax in infants and children with trisomy 21 and without dysmorphic syndrome: Is there a difference in clinical outcome?
21 三体综合征与非畸形综合征婴儿和儿童术后乳糜胸的比较：临床结局是否存在差异？
J Pediatr Surg. 2019 Jul;54(7):1298-1302. doi: 10.1016/j.jpedsurg.2018.06.032. Epub 2018 Jul 6.
4
Evidence-based management of chylothorax in infants.婴儿乳糜胸的循证管理
J Pediatr Surg. 2017 Jun;52(6):907-912. doi: 10.1016/j.jpedsurg.2017.03.010. Epub 2017 Mar 16.
5
Pleurodesis with povidone-iodine for refractory chylothorax in newborns: Personal experience and literature review.聚维酮碘胸膜固定术治疗新生儿难治性乳糜胸：个人经验与文献综述
J Pediatr Surg. 2015 Oct;50(10):1722-5. doi: 10.1016/j.jpedsurg.2015.03.069. Epub 2015 Apr 28.
6
Successful pleurodesis with OK-432 in preterm infants with persistent pleural effusion.用溶链菌制剂对持续性胸腔积液的早产儿进行胸膜固定术取得成功。
Korean J Pediatr. 2012 May;55(5):177-80. doi: 10.3345/kjp.2012.55.5.177. Epub 2012 May 21.
7
OK-432 therapy for chylous pleural effusion or ascites associated with lymphatic malformations.OK-432 疗法治疗淋巴管畸形相关乳糜性胸腔积液或腹水。
J Pediatr Surg. 2010 Sep;45(9):e7-10. doi: 10.1016/j.jpedsurg.2010.06.010.
8
Massive chylothorax in small babies.小婴儿的大量乳糜胸
J Pediatr Surg. 2009 Mar;44(3):546-50. doi: 10.1016/j.jpedsurg.2008.08.008.
9
Treatment with OK-432 for persistent congenital chylothorax in newborn infants resistant to octreotide.用溶链菌制剂治疗对奥曲肽耐药的新生儿持续性先天性乳糜胸。
J Pediatr Surg. 2009 Mar;44(3):e37-9. doi: 10.1016/j.jpedsurg.2008.12.008.
10
OK-432 therapy for unresectable lymphangiomas in children.
J Pediatr Surg. 1991 Mar;26(3):263-8; discussion 268-70. doi: 10.1016/0022-3468(91)90500-s.