Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Cardiology, The Medical School of Southeast University, Nanjing, China.
Front Endocrinol (Lausanne). 2022 May 6;13:865009. doi: 10.3389/fendo.2022.865009. eCollection 2022.
Visceral fat has been considered an important risk factor of elevated serum uric acid (SUA). Perirenal fat is a unique visceral fat around the kidneys that has special morphological and physiological features while its relationship with SUA remains incompletely elucidated. This study aimed to assess the association between perirenal fat volume (PrFV) and SUA.
A cross-sectional study was conducted in 102 subjects aged ≥ 18 years old recruited from Nanjing,China. The clinical characteristics including age, sex, drinking behavior, history of hypertension, body mass index, waist circumference, total cholesterol, fast plasma glucose, urea, serum creatinine, C-reactive protein, and SUA were recorded. PrFV was measured by ultrasonography. Multivariate linear models and the restricted cubic spline were used to investigate the association between PrFV and SUA.
The median age of this study population was 52.5 (42.0-60.0) years and 56.9% were female. The median value of SUA was 5.73 mg/dL (4.58-6.80 mg/dL). The subjects were divided by PrFV tertiles and we found that the subjects in the highest PrFV tertile had a higher level of SUA compared to those in the lowest tertile (β=1.86, 95%CI 1.23-2.48, for trend <0.001).The positive association also remained after adjustment for potential covariates (tertile3 versus tertile1: β=0.99, 95%CI 0.35-1.63, for trend =0.005). There was an increase of approximately 0.53 mg/dL in SUA per 1-fold increase in PrFV (β=0.53, 95%CI 0.02-1.04, for nonlinearity = 0.637).
Our results confirmed a positive independent relationship between PrFV and SUA in Chinese adults. This study suggested that perirenal fat might constitute a potential risk factor for elevated serum uric acid levels.
内脏脂肪被认为是血清尿酸（SUA）升高的一个重要危险因素。肾周脂肪是一种独特的位于肾脏周围的内脏脂肪，具有特殊的形态和生理特征，但其与 SUA 的关系尚未完全阐明。本研究旨在评估肾周脂肪体积（PrFV）与 SUA 之间的关系。
本研究为横断面研究，共纳入 102 名年龄≥18 岁的受试者，来自中国南京。记录了临床特征，包括年龄、性别、饮酒行为、高血压史、体重指数、腰围、总胆固醇、空腹血糖、尿素、血清肌酐、C 反应蛋白和 SUA。使用超声测量 PrFV。采用多元线性模型和限制立方样条模型来探讨 PrFV 与 SUA 之间的关系。
本研究人群的中位年龄为 52.5（42.0-60.0）岁，56.9%为女性。SUA 的中位数为 5.73mg/dL（4.58-6.80mg/dL）。根据 PrFV 三分位将受试者进行分组，我们发现 PrFV 最高三分位的受试者的 SUA 水平高于最低三分位的受试者（β=1.86，95%CI 1.23-2.48，趋势<0.001）。在调整了潜在混杂因素后，这种正相关仍然存在（三分位 3 与三分位 1：β=0.99，95%CI 0.35-1.63，趋势=0.005）。PrFV 每增加 1 倍，SUA 增加约 0.53mg/dL（β=0.53，95%CI 0.02-1.04，非线性=0.637）。
本研究结果证实了中国成年人 PrFV 与 SUA 之间存在正相关的独立关系。本研究提示肾周脂肪可能是血清尿酸水平升高的一个潜在危险因素。
