Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
BMC Endocr Disord. 2022 Aug 20;22(1):210. doi: 10.1186/s12902-022-01081-9.
Obesity is an important risk factor for hyperuricemia. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM).
This was a cross-sectional study involving 257 patients with T2DM recruited from Beijing Luhe Hospital from September 2019 to May 2020. The basic and clinical information such as age, gender, duration of diabetes was collected through the medical records. All patients underwent a physical examination including height, weight, waist circumference, hip circumference, systolic blood pressures and diastolic blood pressure. The venous blood and urine samples were collected to measure SUA, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, serum creatinine, blood urea nitrogen and glycosylated hemoglobin. PrFT and PnFT were measured via ultrasonography. Pearson correlation test and linear regression analysis were used to analyze the association between PrFT and PnFT and SUA.
We found that PrFT and PnFT increased according to the tertiles of SUA level (P = 0.001 and P = 0.009, respectively). In addition, the PrFT and PnFT were positively associated with SUA level (r = 0.25, P < 0.001, r = 0.23, P < 0.001, respectively). Moreover, this association was stronger in males, non-obesity patients and patients with normal renal function. In the multivariate analysis, the PrFT was independently associated with SUA level after adjusting confounding factors.
The PrFT was independently associated with SUA level in patients with T2DM.
肥胖是高尿酸血症的一个重要危险因素。我们旨在探讨 2 型糖尿病（T2DM）患者的腹膜后脂肪厚度（PrFT）和肾周脂肪厚度（PnFT）与血清尿酸（SUA）之间的关系。
这是一项横断面研究，纳入了 2019 年 9 月至 2020 年 5 月期间来自北京潞河医院的 257 名 T2DM 患者。通过病历收集了年龄、性别、糖尿病病程等基本和临床信息。所有患者均进行了体格检查，包括身高、体重、腰围、臀围、收缩压和舒张压。采集静脉血和尿液样本，以测量 SUA、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血清肌酐、血尿素氮和糖化血红蛋白。通过超声测量 PrFT 和 PnFT。采用 Pearson 相关检验和线性回归分析评估 PrFT 和 PnFT 与 SUA 之间的相关性。
我们发现，PrFT 和 PnFT 随 SUA 水平的三分位升高而增加（P = 0.001 和 P = 0.009）。此外，PrFT 和 PnFT 与 SUA 水平呈正相关（r = 0.25，P < 0.001，r = 0.23，P < 0.001）。此外，这种相关性在男性、非肥胖患者和肾功能正常的患者中更强。在多变量分析中，在调整混杂因素后，PrFT 与 SUA 水平独立相关。
PrFT 与 T2DM 患者的 SUA 水平独立相关。
