Wang Yabin, Wang Wenzhen, Kong Fangong, Zhang Qiu, Xiao Jiaqi, Zhang Yi, Yan Bing
State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology, Shandong Academy of Science Jinan China.
Advanced Research Institute for Multidisciplinary Science Qilu University of Technology, Shandong Academy of Science Jinan China.
Bioeng Transl Med. 2021 Nov 24;7(2):e10269. doi: 10.1002/btm2.10269. eCollection 2022 May.
Exosomes are lipid bilayer vesicles released from cells as a mechanism of intracellular communication. Containing information molecules of their parental cells and inclining to fuse with targeted cells, exosomes are valuable in disease diagnosis and drug delivery. The realization of their clinic applications still faces difficulties, such as lacking technologies for fast purification and functional reading. The advancement of nanotechnology in recent decades makes it promising to overcome these difficulties. In this article, we summarized recent progress in utilizing the physiochemical properties of nanoparticles (NPs) to enhance exosome purification and detection sensitivity or to derive novel technologies. We also discussed the valuable applications of exosomes in NPs-based drug delivery. Till now most studies in these fields are still at the laboratory research stage. Translation of these bench works into clinic applications still has a long way to go.
外泌体是细胞释放的脂质双层囊泡，作为细胞内通讯的一种机制。外泌体包含其亲代细胞的信息分子，并倾向于与靶细胞融合，在疾病诊断和药物递送方面具有重要价值。其临床应用的实现仍面临困难，如缺乏快速纯化和功能读取技术。近几十年来纳米技术的进步使其有望克服这些困难。在本文中，我们总结了利用纳米颗粒（NPs）的物理化学性质来提高外泌体纯化和检测灵敏度或衍生新技术的最新进展。我们还讨论了外泌体在基于NPs的药物递送中的重要应用。到目前为止，这些领域的大多数研究仍处于实验室研究阶段。将这些实验室工作转化为临床应用仍有很长的路要走。
