Horgas Ann L, Elliott Amanda L, Yang Shuang, Guo Yi
Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, Gainesville, FL, USA.
Department of Psychiatry, College of Medicine, University of South Florida, Tampa, FL, USA.
SAGE Open Med. 2022 May 17;10:20503121221095923. doi: 10.1177/20503121221095923. eCollection 2022.
We investigated cross-sectional relationships between arthritis or joint-related pain intensity and subjective cognitive decline in middle-aged and older adults.
The sample consisted of 30,150 adults ⩾age 45 years with self-reported arthritis or joint conditions who completed key variables in the 2015 wave of the Behavioral Risk Factor Surveillance System.
Using weighted data, 94.2% of the sample reported experiencing joint pain in the last month (35.9% reported moderate pain and 30.6% reported severe pain) and 17.3% reported subjective cognitive decline. In logistic regression models, pain intensity was associated with significantly higher odds of reporting subjective cognitive decline, after controlling for age, race/ethnicity, sex, education, household income, cardiovascular health, mental health, and history of stroke. Those with moderate pain were two times as likely to report subjective cognitive decline and those with severe pain were more than three times as likely to report subjective cognitive decline relative to those without pain, adjusting for covariates.
The results of this study highlight a significant relationship between pain intensity and subjective cognitive decline in middle-aged and older adults with arthritis or joint conditions typically associated with joint pain. Moderate and severe joint pain is significantly associated with higher risk of subjective cognitive decline, after controlling for personal and health characteristics. Future studies with more comprehensive assessments of pain and cognition are warranted to further elucidate these relationships and their underlying mechanisms.
我们研究了中老年成年人中关节炎或关节相关疼痛强度与主观认知衰退之间的横断面关系。
样本包括30150名年龄在45岁及以上且自我报告患有关节炎或关节疾病的成年人，他们在2015年行为危险因素监测系统调查中完成了关键变量的填写。
使用加权数据，94.2%的样本报告在过去一个月中经历过关节疼痛（35.9%报告为中度疼痛，30.6%报告为重度疼痛），17.3%报告有主观认知衰退。在逻辑回归模型中，在控制了年龄、种族/民族、性别、教育程度、家庭收入、心血管健康、心理健康和中风史之后，疼痛强度与报告主观认知衰退的较高几率显著相关。在调整协变量后，与无疼痛者相比，中度疼痛者报告主观认知衰退的可能性是其两倍，重度疼痛者报告主观认知衰退的可能性是其三倍多。
本研究结果凸显了在患有关节炎或通常与关节疼痛相关的关节疾病的中老年成年人中，疼痛强度与主观认知衰退之间的显著关系。在控制个人和健康特征后，中度和重度关节疼痛与主观认知衰退的较高风险显著相关。有必要开展对疼痛和认知进行更全面评估的未来研究，以进一步阐明这些关系及其潜在机制。
