天然草药作为通过调节血管生成治疗心肌梗死的策略。
Natural Herbal Medicine as a Treatment Strategy for Myocardial Infarction through the Regulation of Angiogenesis.
作者信息
Zhang Mu-Xin, Song Yu, Xu Wan-Li, Zhang Ling-Xiao, Li Chao, Li Yun-Lun
机构信息
First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
出版信息
Evid Based Complement Alternat Med. 2022 May 12;2022:8831750. doi: 10.1155/2022/8831750. eCollection 2022.
METHODS
We conducted a literature search on the bioactive components of medicinal plants and their effects on angiogenesis after MI. We searched for articles in Web of Science, MEDLINE, PubMed, Scopus, Google Scholar, and China National Knowledge Infrastructure databases before April 2021.
RESULTS
In this article, we summarized the mechanisms by which copper ions, microRNA, Akt1, inflammation, oxidative stress, mitochondria, and pericytes are involved in angiogenesis after myocardial infarction. In addition, we reviewed the angiogenic effects of natural herbal medicines such as Bunge Bunge, L., , , C.A. Mey., (Burkill) F.H. Chen, (L.) J. Presl, (Gaertn.) DC., Houtt, Georgi., and Willd.
CONCLUSIONS
Some herbs have the effect of promoting angiogenesis. In the future, natural proangiogenic drugs may become candidates for the treatment of cardiovascular diseases.
方法
我们对药用植物的生物活性成分及其对心肌梗死后血管生成的影响进行了文献检索。我们在2021年4月之前在科学网、MEDLINE、PubMed、Scopus、谷歌学术和中国知网数据库中搜索文章。
结果
在本文中，我们总结了铜离子、微小RNA、Akt1、炎症、氧化应激、线粒体和周细胞参与心肌梗死后血管生成的机制。此外，我们综述了诸如 Bunge Bunge、L.、 、 、C.A. Mey.、 （Burkill）F.H. Chen、 （L.）J. Presl、 （Gaertn.）DC.、Houtt、Georgi. 和 Willd. 等天然草药的血管生成作用。
结论
一些草药具有促进血管生成的作用。未来，天然促血管生成药物可能成为治疗心血管疾病的候选药物。
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