Department of Pediatrics, Yiwu Central Hospital, Yiwu 322000, Zhejiang, China.
Department of Pharmacy, Yiwu Central Hospital, Yiwu 322000, Zhejiang, China.
Contrast Media Mol Imaging. 2022 May 4;2022:6460865. doi: 10.1155/2022/6460865. eCollection 2022.
The aim of this study was to investigate the value of high-resolution computed tomography (CT) images and mycoplasma (MP) ribonucleic acid (RNA) load detection in the early diagnosis of refractory mycoplasma (RMP) and provide more methods for the diagnosis and treatment of RMP. Seventy children with MP were divided into the RMP group (H1 group, 31 cases) and the MP group (H2 group, 39 cases) according to pathological findings, and all of them underwent CT scanning. MP-RNA load and genotype distribution were analyzed in both groups, and the diagnostic efficacy of CT combined with MP-RNA load for RMP was calculated. The sensitivity of children in the H1 group to erythromycin (59.17% vs 71.56%) and clarithromycin (53.21% vs 67.03%) was lower than that in the H2 group, and the resistance rate of children in the H1 group to erythromycin (71.43% vs 67.53%) and clarithromycin (64.24% vs 50.37%) was higher than that in the H2 group ( < 0.05); the regression coefficients between lactate dehydrogenase (LDH) and the MPLI value of RMP were -0.064 and -0.413, respectively, which were significantly negatively correlated ( < 0.05); the accuracy (96.5%), sensitivity (92.5%), and specificity (88%) of CT + MP-RNA in the diagnosis of RMP were significantly higher than those of CT alone (91%, 88%, and 82%) and MP-RNA alone (88%, 84.5%, and 74%), which were significantly different ( < 0.05). The results of high MP-RNA load detection can be used as an indicator to predict RMP, and the diagnostic efficacy is significantly improved after combination with high-resolution CT, with high clinical application value.
本研究旨在探讨高分辨率计算机断层扫描（CT）图像和支原体（MP）核糖核酸（RNA）载量检测在难治性支原体（RMP）早期诊断中的价值，为 RMP 的诊断和治疗提供更多方法。70 例 MP 患儿根据病理结果分为 RMP 组（H1 组，31 例）和 MP 组（H2 组，39 例），均行 CT 扫描。分析两组 MP-RNA 载量及基因型分布，计算 CT 联合 MP-RNA 载量对 RMP 的诊断效能。H1 组儿童对红霉素（59.17%比 71.56%）和克拉霉素（53.21%比 67.03%）的敏感性低于 H2 组，H1 组儿童对红霉素（71.43%比 67.53%）和克拉霉素（64.24%比 50.37%）的耐药率高于 H2 组（ < 0.05）；乳酸脱氢酶（LDH）与 RMP MPLI 值的回归系数分别为-0.064 和-0.413，均呈显著负相关（ < 0.05）；CT+MP-RNA 对 RMP 的诊断准确率（96.5%）、灵敏度（92.5%）和特异度（88%）均明显高于 CT 单独诊断（91%、88%和 82%）和 MP-RNA 单独诊断（88%、84.5%和 74%），差异均有统计学意义（ < 0.05）。高 MP-RNA 载量检测结果可作为预测 RMP 的指标，与高分辨率 CT 联合诊断可显著提高诊断效能，具有较高的临床应用价值。
