Kim Young Jin, Park Ji Won, Lim Han-Ki, Kwon Yoon-Hye, Kim Min Jung, Choe Eun Kyung, Moon Sang Hui, Ryoo Seung-Bum, Jeong Seung-Yong, Park Kyu Joo
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
J Minim Invasive Surg. 2020 Dec 15;23(4):186-190. doi: 10.7602/jmis.2020.23.4.186.
Endoscopic tattooing is used to mark colorectal lesions for subsequent surgery. As a tattooing agent, India ink has been widely used but is not currently available in Korea. Indocyanine green (ICG) can be applied as an alternative agent. However, studies on colonoscopic tattooing by the direct injection of indocyanine green are lacking. This study aimed to compare the efficacy and safety between an ICG direct injection method and an India ink saline test injection method.
A total of 227 patients who underwent preoperative endoscopic tattooing for colorectal neoplasm (149 patients in the ICG direct injection group and 78 patients in the India ink saline test injection group) were included in the study. The efficacy of the two methods was compared by visualization and safety was compared by evaluating the perioperative tattooing complications.
The visualization of lesions in the ICG group was not different from that of the India ink group (p=0.42, 96.0% vs 98.7%, respectively). Only one patient in the ICG group had abdominal pain related to tattooing, but no complications developed in the India ink group.
Considering the good visualization and low complication rate, the direct injection of ICG can be used as an alternative tattooing method.
内镜下纹身用于标记结直肠病变以便后续手术。作为一种纹身剂，印度墨水已被广泛使用，但目前在韩国无法获取。吲哚菁绿（ICG）可作为替代剂应用。然而，关于通过直接注射吲哚菁绿进行结肠镜纹身的研究尚缺。本研究旨在比较ICG直接注射法与印度墨水生理盐水试验注射法之间的疗效和安全性。
本研究纳入了总共227例因结直肠肿瘤接受术前内镜纹身的患者（ICG直接注射组149例患者，印度墨水生理盐水试验注射组78例患者）。通过观察比较两种方法的疗效，并通过评估围手术期纹身并发症比较安全性。
ICG组病变的可视性与印度墨水组无异（p = 0.42，分别为96.0%和98.7%）。ICG组仅1例患者出现与纹身相关的腹痛，而印度墨水组未发生并发症。
鉴于良好的可视性和低并发症发生率，直接注射ICG可作为一种替代纹身方法。
