将慢性阻塞性肺疾病治疗与为期8周的太极拳练习相结合：身心干预与神经机制探索
Integrating Chronic Obstructive Pulmonary Disease Treatment With 8-Week Tai Chi Chuan Practice: An Exploration of Mind-Body Intervention and Neural Mechanism.
作者信息
Shen Haoran, Chen Li-Zhen, Hu Zhuoer, Yao Xiaoyan, Yang Tao, Zhang Lan, Tu Qiang, Li Guangxi, Wei Gao-Xia
机构信息
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
出版信息
Front Hum Neurosci. 2022 May 6;16:849481. doi: 10.3389/fnhum.2022.849481. eCollection 2022.
OBJECTIVE
This study aims to explore the effect of integrating routine treatment with Tai Chi Chuan (TCC) intervention on the clinical symptom of patients with Chronic Obstructive Pulmonary Disease (COPD) from clinical and neurological perspectives.
METHODS
Twenty patients with COPD were recruited for regular treatment combined with 8-week TCC rehabilitative practice. Clinical symptoms were evaluated by Chronic Obstructive Pulmonary Symptom Assessment Scale (CAT) and Modified Dyspnea Scale (mMRC) at baseline and after treatment. Resting-state MRI scan was also performed with multiline T2-weighted echo-planar imaging (EPI) to acquire their functional images before and after the treatment. TCC rehabilitation involved a total of 8 weeks of practice with 90 min per session, three times a week.
RESULTS
After an 8-week integration routine treatment with TCC practice, the patient's clinical symptoms improved significantly. Imaging analysis showed that COPD patients exhibited decreased Degree of Centrality (DC) in the right inferior frontal gyrus (IFG), right middle frontal gyrus, bilateral cingulate cortex, bilateral precuneus, and right precentral gyrus. Moreover, correlation analysis found that the decreased DC in the right IFG was positively correlated with the CAT improvements.
CONCLUSION
The routine treatment involving TCC rehabilitation practice could improve the clinical symptoms of patients with COPD. The right IFG might be a key brain region to contribute to the neural mechanism underlying integrative intervention on the clinical symptoms in COPD. These findings provide neurological evidence for treating COPD rehabilitation practice with mind-body practice based on Chinese culture to some extent, which also advances the understanding of the efficacy of TCC as the adjuvant technology from a neuroscience perspective.
CLINICAL TRIAL REGISTRATION
[http://www.chictr.org.cn/showproj.aspx?proj=45189], identifier [ChiCTR1900028335].
目的
本研究旨在从临床和神经学角度探讨常规治疗与太极拳（TCC）干预相结合对慢性阻塞性肺疾病（COPD）患者临床症状的影响。
方法
招募20例COPD患者进行常规治疗，并结合为期8周的太极拳康复练习。在基线和治疗后，采用慢性阻塞性肺疾病症状评估量表（CAT）和改良呼吸困难量表（mMRC）评估临床症状。还采用多线T2加权回波平面成像（EPI）进行静息态MRI扫描，以获取治疗前后的功能图像。太极拳康复共进行8周，每次练习90分钟，每周三次。
结果
经过8周的常规治疗与太极拳练习相结合，患者的临床症状有显著改善。影像学分析显示，COPD患者右下额叶回（IFG）、右额中回、双侧扣带回皮质、双侧楔前叶和右中央前回的中心性程度（DC）降低。此外，相关性分析发现，右IFG中DC的降低与CAT的改善呈正相关。
结论
包含太极拳康复练习的常规治疗可改善COPD患者的临床症状。右IFG可能是COPD临床症状综合干预潜在神经机制的关键脑区。这些发现为基于中国文化的身心练习用于COPD康复治疗提供了一定的神经学证据，也从神经科学角度推进了对太极拳作为辅助技术疗效的理解。
临床试验注册
[http://www.chictr.org.cn/showproj.aspx?proj=45189]，标识符[ChiCTR1900028335]
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