头颈部腺样囊性癌中叶酸受体α的蛋白表达
Protein Expression of Folate Receptor Alpha in Adenoid Cystic Carcinoma of the Head and Neck.
作者信息
Schnoell Julia, Jank Bernhard J, Kadletz-Wanke Lorenz, Stoiber Stefan, Gurnhofer Elisabeth, Schlederer Michaela, Heiduschka Gregor, Kenner Lukas
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, 1090, Austria.
Department of Pathology, Medical University of Vienna, Vienna, Austria.
出版信息
Onco Targets Ther. 2022 May 16;15:531-538. doi: 10.2147/OTT.S351500. eCollection 2022.
PURPOSE
Folate receptor alpha (FRα) is overexpressed in various cancer entities while expression in normal tissue is limited. Thus, FRα is an attractive target in cancer therapy. Currently, various therapeutic and diagnostic approaches are under investigation in clinical trials. The aim of this study was to assess the expression and clinical relevance of FRα in adenoid cystic carcinoma of the head and neck.
PATIENTS AND METHODS
In this retrospective cohort study, 43 patients with adenoid cystic carcinoma (ACC) of the head and neck were included. FRα expression was analyzed in tumor tissue and tumor-free margin in a tissue microarray using immunohistochemical staining. Protein levels were correlated with clinical parameters.
RESULTS
FRα staining was positive in 47% of ACC patients. The tumor-free margin was positive in 22%. Patients with positive tumor tissue showed positive margin staining in 55%. FRα expression was not associated with the clinical parameters (sex, age, staging, grading, perineural invasion, lymphovascular invasion).
CONCLUSION
FRα expression is common in ACC of the head and neck. Therefore, FRα should be further evaluated as a therapeutic target in ACC.
目的
叶酸受体α（FRα）在多种癌症实体中过度表达，而在正常组织中的表达有限。因此，FRα是癌症治疗中一个有吸引力的靶点。目前，各种治疗和诊断方法正在临床试验中进行研究。本研究的目的是评估FRα在头颈部腺样囊性癌中的表达及临床相关性。
患者和方法
在这项回顾性队列研究中，纳入了43名头颈部腺样囊性癌（ACC）患者。使用免疫组织化学染色在组织微阵列中分析肿瘤组织和无瘤切缘中的FRα表达。蛋白质水平与临床参数相关。
结果
47%的ACC患者FRα染色呈阳性。无瘤切缘阳性率为22%。肿瘤组织阳性的患者中，切缘染色阳性率为55%。FRα表达与临床参数（性别、年龄、分期、分级、神经周围浸润、淋巴管浸润）无关。
结论
FRα表达在头颈部ACC中很常见。因此，FRα应作为ACC的治疗靶点进一步评估。
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