Napoli V M, Symbas P J, Vroon D H, Symbas P N
J Trauma. 1987 Mar;27(3):296-300.
The coagulation system was investigated in five dogs undergoing autotransfusion from experimental hemothorax. One fourth of the blood volume was bled into the pleural space, drained, and autotransfused. The hemothorax blood showed: very prolonged PT and PTT; very low platelets and fibrinogen; midly elevated FDP; very low coagulation factors VIII, and V; reduced XII, prothrombin, X, XI, and VII. Partial clotting, mild fibrinolysis, and fibrin deposition over the pulmonary pleura seemed to cause incoagulability of hemothorax blood. Post autotransfusion arterial blood showed: normal PT and PTT; 25% decrease in platelets, and 31% decrease in fibrinogen from baseline values. There was also an overall 20% reduction of fibrinogen from baseline values. There was also an overall 20% reduction of all clotting factors, but their levels remained above 50% activity. It was concluded that autotransfusion from a hemothorax of 25% the blood volume in dogs causes a mild loss of hemostatic components, but does not significantly compromise the clotting mechanism.
对五只接受实验性血胸自体输血的犬的凝血系统进行了研究。将四分之一血容量的血液注入胸腔，引流后进行自体输血。血胸血液显示：凝血酶原时间（PT）和活化部分凝血活酶时间（PTT）非常延长；血小板和纤维蛋白原极低；纤维蛋白降解产物（FDP）轻度升高；凝血因子VIII和V极低；因子XII、凝血酶原、因子X、因子XI和因子VII减少。部分凝血、轻度纤维蛋白溶解以及肺胸膜上的纤维蛋白沉积似乎导致了血胸血液的不可凝性。自体输血后的动脉血显示：PT和PTT正常；血小板较基线值降低25%，纤维蛋白原较基线值降低31%。纤维蛋白原较基线值总体降低20%。所有凝血因子总体也降低20%，但其水平仍保持在50%以上的活性。得出的结论是，犬自体输血量为血容量25%的血胸血会导致止血成分轻度丢失，但不会显著损害凝血机制。
