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接骨木的使用与自身免疫性肝炎之间可能存在的关联。

A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis.

作者信息

Ramachandran Akshaya, Antala Drashti, Pudasainee Prasun, Panginikkod Sreelakshmi, Gupta Harsh

机构信息

Internal Medicine, AMITA Saint Francis Hospital, Evanston, USA.

Internal Medicine, AMITA Health Saint Francis Hospital, Evanston, USA.

出版信息

Cureus. 2022 Apr 18;14(4):e24250. doi: 10.7759/cureus.24250. eCollection 2022 Apr.

DOI:10.7759/cureus.24250
PMID:35602846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9116981/
Abstract

Hepatic injury due to dietary and herbal supplements can often share similar clinical characteristics with autoimmune hepatitis (AIH). species, commonly known as elderberry, have been used in traditional medicine for centuries to prevent and treat respiratory problems. Although there are no clear reports on the association of elderberry with AIH or drug-induced hepatitis, there have been concerns about negative health manifestations linked to elderberry and the overproduction of inflammatory cytokines. In this article, we discuss a case of a patient who developed autoimmune hepatitis while on long-term elderberry-containing supplements and a probable association between the two.

摘要

饮食和草药补充剂引起的肝损伤通常与自身免疫性肝炎(AIH)具有相似的临床特征。接骨木属植物,俗称接骨木果,几个世纪以来一直在传统医学中用于预防和治疗呼吸道问题。虽然目前尚无关于接骨木与自身免疫性肝炎或药物性肝炎关联的明确报道,但人们一直担心接骨木与炎症细胞因子过度产生相关的负面健康表现。在本文中,我们讨论了一例在长期服用含接骨木补充剂期间发生自身免疫性肝炎的患者病例以及两者之间可能存在的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0a/9116981/6ded514e2481/cureus-0014-00000024250-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0a/9116981/1d64cd723ac3/cureus-0014-00000024250-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0a/9116981/6ded514e2481/cureus-0014-00000024250-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0a/9116981/1d64cd723ac3/cureus-0014-00000024250-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0a/9116981/6ded514e2481/cureus-0014-00000024250-i02.jpg

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本文引用的文献

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Front Immunol. 2021 Sep 28;12:746436. doi: 10.3389/fimmu.2021.746436. eCollection 2021.
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Botanical drugs and supplements affecting the immune response in the time of COVID-19: Implications for research and clinical practice.在 COVID-19 期间影响免疫反应的植物药和补充剂:对研究和临床实践的影响。
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具有自身免疫表型的药物性肝损伤自身抗体谱的探索性研究
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Structural characterisation and immunomodulatory activity of a neutral polysaccharide from Sambucus adnata Wall.糖结构表征及腺肋花楸中性多糖的免疫调节活性
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