Cirer-Sastre Rafel, Jiménez-Gaytán Romario, Carranza-García Luis Enrique, George Keith, Apple Fred S, Navarro-Orocio Ricardo, López-García Ricardo, Reverter-Masía Joaquín, Mayolas-Pi Carmen, Morales-Corral Pedro Gualberto, Legaz-Arrese Alejandro
Institut Nacional d'Educació Física de Catalunya (INEFC), Universitat de Lleida (UdL), Lleida, Spain.
Autonomous University of Nuevo Leon, School of Sports Organization, Nuevo León, Mexico.
Biomarkers. 2022 Nov;27(7):619-624. doi: 10.1080/1354750X.2022.2080272. Epub 2022 Jun 23.
Post-exercise elevations of cardiac troponin T (cTnT) and I (cTnI) are often used in isolation but interpreted interchangeably. Research suggests, however, that post-exercise cTn kinetic might differ with each isoform. In this cross-sectional observational study, we collected blood samples before, immediately after (5 minutes), and at 1-, 3-, 6-, 12-, and 24-hour post-exercise in a mixed cohort of 56 participants after a distance-trial of 60 min continuous swimming (age range from 14 to 22, 57.1% female). Cardiac troponin kinetics were modelled using Bayesian mixed-effects models to estimate time to peak (TTP) and peak concentration (PC) for each isoform, while controlling for participants sex, tanner stage and average relative heart rate during the test. Exercise induced an elevation of cTnT and cTnI in 93% and 75% of the participants, respectively. Cardiac troponin T peaked earlier, at 2.9 h (CI: 2.6 - 3.2 h) post-exercise, whereas cTnI peaked later, at 4.5 h (CI: 4.2 - 4.9 h). Peak concentrations for cTnT and cTnI were 2.5 ng/L, CI: 0 - 11.2 ng/L and 2.16 ng/L, CI: 0 - 22.7 ng/L, respectively. Additionally, we did not observe a systematic effect of sex and maturational status mediating cTn responses.
运动后心肌肌钙蛋白T（cTnT）和心肌肌钙蛋白I（cTnI）升高常被单独使用，但解释时却可互换。然而，研究表明，运动后cTn的动力学可能因每种异构体而异。在这项横断面观察性研究中，我们在56名参与者的混合队列中，于60分钟持续游泳耐力试验前、运动后即刻（5分钟）以及运动后1、3、6、12和24小时采集血样（年龄范围为14至22岁，女性占57.1%）。使用贝叶斯混合效应模型对心肌肌钙蛋白动力学进行建模，以估计每种异构体的达峰时间（TTP）和峰值浓度（PC），同时控制参与者的性别、坦纳分期和测试期间的平均相对心率。运动分别使93%和75%的参与者cTnT和cTnI升高。心肌肌钙蛋白T在运动后2.9小时（CI：2.6 - 3.2小时）较早达到峰值，而cTnI在4.5小时（CI：4.2 - 4.9小时）较晚达到峰值。cTnT和cTnI的峰值浓度分别为2.5 ng/L（CI：0 - 11.2 ng/L）和2.16 ng/L（CI：0 - 22.7 ng/L）。此外，我们未观察到性别和成熟状态对cTn反应有系统性影响。
