Chester J F, Gaissert H A, Ross J S, Malt R A, Weitzman S A
J Urol. 1987 Apr;137(4):769-71. doi: 10.1016/s0022-5347(17)44207-8.
The augmenting effect of chronic inflammation on bladder cancer was studied in female Swiss mice treated with N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT), 0.15% by weight of diet for 20 weeks. To produce chronic inflammation one silk suture and one catgut suture were placed through the bladder wall of 63 mice to receive FANFT and 18 to receive normal diet. In remaining mice (no. = 62) the bladder was simply touched without suture insertion. Thirty-two animals treated with FANFT and 33 treated with FANFT + sutures also received supplements to their drinking water throughout the experiment of the sulfhydryl-reducing agent N-acetylcysteine (500 mg./kg. body weight/day). Seven weeks following FANFT treatment, bladder cancers developed in 12% of mice with sutures and FANFT and in 19% of those with sutures, FANFT, and N-acetylcysteine. No cancers developed in mice receiving FANFT alone or FANFT with N-acetylcysteine and none in mice treated with sutures only. Placement of silk sutures through the bladder wall of mice augments FANFT-induced bladder cancer. N-acetylcysteine at these doses does not influence the incidence.
在喂食含0.15%（重量比）N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺（FANFT）的饲料20周的雌性瑞士小鼠中，研究了慢性炎症对膀胱癌的增强作用。为了产生慢性炎症，将一根丝线缝合线和一根肠线缝合线穿过63只接受FANFT的小鼠的膀胱壁，18只接受正常饮食的小鼠则不做处理。其余62只小鼠的膀胱仅被触摸而不插入缝合线。在整个实验过程中，32只接受FANFT治疗的动物和33只接受FANFT + 缝合线治疗的动物的饮用水中还添加了巯基还原剂N-乙酰半胱氨酸（500毫克/千克体重/天）。FANFT治疗7周后，接受缝合线和FANFT治疗的小鼠中有12%发生了膀胱癌，接受缝合线、FANFT和N-乙酰半胱氨酸治疗的小鼠中有19%发生了膀胱癌。单独接受FANFT或接受FANFT与N-乙酰半胱氨酸治疗的小鼠均未发生癌症，仅接受缝合线治疗的小鼠也未发生癌症。将丝线缝合线穿过小鼠膀胱壁会增强FANFT诱导的膀胱癌。这些剂量的N-乙酰半胱氨酸不影响发病率。
