Trachtenberg J
J Urol. 1987 Apr;137(4):785-8. doi: 10.1016/s0022-5347(17)44211-x.
In order to determine if intermittent hormonal therapy might prove to be beneficial in the treatment of prostatic cancer, animals bearing the Dunning R3327H prostatic adenocarcinoma were castrated and intermittently subjected to hormonal stimulation by means of indwelling silastic testosterone-filled implants. The growth of these tumors, as measured by increases in volume, was compared to that of a castrate control group, a chronic implant group and an intact control group. By the end of an initial 49 day experimental period there was no significant growth reduction with the intermittent stimulation group as compared to the implanted control or intact groups. The castrate group had a significant lower rate of growth than any other group. The incidence of massive tumor growth or tumor necrosis was significantly lower in the castrate group than the other groups by the end of the 16 week experimental period. Intermittent hormonal therapy is clearly inferior to early castration in preventing tumor growth; furthermore it does not appear to offer any growth-retarding advantages when compared to delayed hormone therapy. The most effective growth-retarding technique for the Dunning R3327H hormone dependent prostatic adenocarcinoma is early castration.
为了确定间歇性激素疗法是否可能被证明对前列腺癌的治疗有益，对携带邓宁R3327H前列腺腺癌的动物进行去势，并通过留置填充有睾酮的硅橡胶植入物间歇性地给予激素刺激。将这些肿瘤的生长情况（通过体积增加来衡量）与去势对照组、慢性植入组和完整对照组进行比较。在最初的49天实验期结束时，与植入对照组或完整组相比，间歇性刺激组的肿瘤生长没有显著降低。去势组的生长速度明显低于其他任何组。在16周实验期结束时，去势组中大量肿瘤生长或肿瘤坏死的发生率明显低于其他组。间歇性激素疗法在预防肿瘤生长方面明显不如早期去势；此外，与延迟激素疗法相比，它似乎没有提供任何延缓生长的优势。对于邓宁R3327H激素依赖性前列腺腺癌，最有效的延缓生长技术是早期去势。
