Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Life Sciences Institute, University of British Columbia, Vancouver, Canada.
J Leukoc Biol. 2022 Nov;112(5):1105-1113. doi: 10.1002/JLB.3AB1220-819RRR. Epub 2022 May 23.
Interleukin-7 is a cytokine with well-established roles in lymphocyte development and more recently, an expanded role in immune function. IL-7Rα is highly expressed by innate lymphoid cells (ILCs), but how IL-7 directs the development or function of ILCs is not well studied. Using mice with inducible deletion of IL-7Rα, we showed that loss of IL-7 signaling led to impaired production of IL-5, IL-13 and amphiregulin in lung ST2 group 2 innate lymphoid cells (ILC2s) following influenza/A infection. Conversely, mice treated with IL-7 increased production of IL-5 and IL-13 by lung ILC2s. Moreover, we showed that IL-7 enhanced GATA3 and CD25 expression in ILC2s and loss of IL-7 signaling led to their reduced expression. Altogether, this study demonstrates that IL-7 regulates the function of ILC2s during airway viral infection and induces GATA3 and CD25 expression.
白细胞介素-7 是一种细胞因子，在淋巴细胞发育中具有明确的作用，最近在免疫功能中具有扩展作用。IL-7Rα 在先天淋巴细胞（ILCs）中高度表达，但 IL-7 如何指导 ILCs 的发育或功能尚未得到很好的研究。使用可诱导性缺失 IL-7Rα 的小鼠，我们发现流感/ A 感染后，IL-7 信号的缺失导致肺 ST2 组 2 先天淋巴细胞（ILC2）中 IL-5、IL-13 和 Amphiregulin 的产生受损。相反，用 IL-7 处理的小鼠增加了肺 ILC2 中 IL-5 和 IL-13 的产生。此外，我们表明 IL-7 增强了 ILC2 中的 GATA3 和 CD25 表达，而 IL-7 信号的缺失导致其表达减少。总之，这项研究表明，IL-7 在气道病毒感染期间调节 ILC2 的功能，并诱导 GATA3 和 CD25 的表达。
