Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
J Leukoc Biol. 2022 Nov;112(5):1013-1023. doi: 10.1002/JLB.3MR0422-665R. Epub 2022 May 23.
Type 2 immune responses are mediated by the cytokines interleukin (IL)-4, IL-5, IL-10, and IL-13 and associated cell types, including T helper (Th)2 cells, group 2 innate lymphoid cells (ILC2s), basophils, mast cells, eosinophils, and IL-4- and IL-13-activated macrophages. It can suppress type 1-driven autoimmune diseases, promote antihelminth immunity, maintain cellular metabolic homeostasis, and modulate tissue repair pathways following injury. However, when type 2 immune responses become dysregulated, they can be a significant pathogenesis of many allergic and fibrotic diseases. As such, there is an intense interest in studying the pathways that modulate type 2 immune response so as to identify strategies of targeting and controlling these responses for tissue healing. Herein, we review recent literature on the metabolic regulation of immune cells initiating type 2 immunity and immune cells involved in the effector phase, and talk about how metabolic regulation of immune cell subsets contribute to tissue repair. At last, we discuss whether these findings can provide a novel prospect for regenerative medicine.
2 型免疫反应由细胞因子白细胞介素 (IL)-4、IL-5、IL-10 和 IL-13 以及相关细胞类型介导，包括辅助性 T 细胞 (Th)2 细胞、2 型固有淋巴细胞 (ILC2)、嗜碱性粒细胞、肥大细胞、嗜酸性粒细胞、以及 IL-4 和 IL-13 激活的巨噬细胞。它可以抑制 1 型驱动的自身免疫性疾病，促进抗寄生虫免疫，维持细胞代谢稳态，并在损伤后调节组织修复途径。然而，当 2 型免疫反应失调时，它们可能是许多过敏和纤维化疾病的重要发病机制。因此，人们强烈关注研究调节 2 型免疫反应的途径，以确定针对和控制这些反应以进行组织修复的策略。在此，我们综述了关于启动 2 型免疫的免疫细胞和参与效应阶段的免疫细胞的代谢调节的最新文献，并讨论了免疫细胞亚群的代谢调节如何有助于组织修复。最后，我们讨论了这些发现是否可以为再生医学提供新的前景。
