Nephrology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, Henan, China.
Nephrology (Carlton). 2022 Nov;27(11):851-858. doi: 10.1111/nep.14064. Epub 2022 Jun 5.
Gut microbiota plays a vital role in human intestinal homeostasis, correlating strongly with the progression of numerous diseases. Recent researches provide powerful evidence that the connections exist between gut microbiota and renal anaemia. Gut microbiota may have an impact on renal anaemia by regulating the hypoxia-inducible factor (HIF) signalling, iron metabolism and inflammatory state. Because of this relationship, there may be potential treatments for renal anaemia. In this review, we will first provide an overview of current research progression on anaemia in chronic kidney disease and then introduce the relations among gut microbiota, HIF, and renal anaemia to explore the possible treatment options.
肠道微生物群在人类肠道内环境中起着至关重要的作用，与许多疾病的发展密切相关。最近的研究提供了有力的证据表明，肠道微生物群与肾性贫血之间存在联系。肠道微生物群可能通过调节缺氧诱导因子（HIF）信号、铁代谢和炎症状态来影响肾性贫血。由于这种关系，可能存在针对肾性贫血的潜在治疗方法。在这篇综述中，我们将首先概述慢性肾脏病贫血的研究进展，然后介绍肠道微生物群、HIF 和肾性贫血之间的关系，以探讨可能的治疗选择。
