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择期脊柱手术后持续使用阿片类药物的驱动因素及其对医疗保健利用的影响。

The Drivers of Persistent Opioid Use and Its Impact on Healthcare Utilization After Elective Spine Surgery.

作者信息

Gerlach Erik B, Plantz Mark A, Swiatek Peter R, Wu Scott A, Arpey Nicholas, Fei-Zhang David, Divi Srikanth N, Hsu Wellington K, Patel Alpesh A

机构信息

Department of Orthopaedic Surgery, Northwestern University, Chicago, IL, USA.

出版信息

Global Spine J. 2024 Mar;14(2):370-379. doi: 10.1177/21925682221104731. Epub 2022 May 23.

Abstract

STUDY DESIGN

Retrospective cohort study.

OBJECTIVE

The aim of this study was to determine the incidence of and risk factors for persistent opioid use after elective cervical and lumbar spine procedures and to quantify postoperative healthcare utilization in this patient population.

METHODS

Patients were retrospectively identified who underwent elective spine surgery for either cervical or lumbar degenerative pathology between November 1, 2013, and September 30, 2018, at a single academic center. Patients were split into 2 cohorts, including patients with and without opioid use at 180-days postoperatively. Baseline patient demographics, underlying comorbidities, surgical variables, and preoperative/postoperative opioid use were assessed. Health resource utilization metrics within 1 year postoperatively (ie, imaging studies, emergency and urgent care visits, hospital readmissions, opioid prescriptions, etc.) were compared between these 2 groups.

RESULTS

583 patients met inclusion criteria, of which 16.6% had opioid persistence after surgery. Opioid persistence was associated with ASA score ≥3 (P = .004), diabetes ( = .019), class I obesity ( = .012), and an opioid prescription in the 60 days prior to surgery ( = .006). Independent risk factors for opioid persistence assessed via multivariate regression included multi-level lumbar fusion (RR = 2.957), cervical central stenosis (RR = 2.761), and pre-operative opioid use (RR = 2.668). Opioid persistence was associated with higher rates of health care utilization, including more radiographs ( < .001), computed tomography (CT) scans (.007), magnetic resonance imaging (MRI) studies ( = .014), emergency department (ED) visits (.009), pain medicine referrals (P < .001), and spinal injections ( = .003).

CONCLUSIONS

Opioid persistence is associated with higher rates of health care utilization within 1 year after elective spine surgery.

摘要

研究设计

回顾性队列研究。

目的

本研究旨在确定择期颈椎和腰椎手术后持续使用阿片类药物的发生率及危险因素,并量化该患者群体术后的医疗资源利用情况。

方法

回顾性纳入2013年11月1日至2018年9月30日在单一学术中心因颈椎或腰椎退行性病变接受择期脊柱手术的患者。患者被分为两组,包括术后180天使用和未使用阿片类药物的患者。评估患者的基线人口统计学特征、基础合并症、手术变量以及术前/术后阿片类药物使用情况。比较这两组患者术后1年内的卫生资源利用指标(即影像学检查、急诊和紧急护理就诊、住院再入院、阿片类药物处方等)。

结果

583例患者符合纳入标准,其中16.6%术后存在阿片类药物持续使用情况。阿片类药物持续使用与美国麻醉医师协会(ASA)评分≥3(P = 0.004)、糖尿病(P = 0.019)、I级肥胖(P = 0.012)以及术前60天内开具阿片类药物处方(P = 0.006)相关。通过多因素回归分析评估的阿片类药物持续使用的独立危险因素包括多节段腰椎融合术(相对风险[RR]=2.957)、颈椎中央管狭窄(RR = 2.761)和术前使用阿片类药物(RR = 2.668)。阿片类药物持续使用与更高的医疗资源利用率相关,包括更多的X线片(P < 0.001)、计算机断层扫描(CT)(P = 0.007)、磁共振成像(MRI)检查(P = 0.014)、急诊科(ED)就诊(P = 0.009)、疼痛科转诊(P < 0.001)和脊柱注射(P = 0.003)。

结论

阿片类药物持续使用与择期脊柱手术后1年内更高的医疗资源利用率相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9007/10802539/e340a7a26a7e/10.1177_21925682221104731-fig1.jpg

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