Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Neurocardiology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
CNS Neurosci Ther. 2022 Aug;28(8):1240-1248. doi: 10.1111/cns.13868. Epub 2022 May 23.
The relationship between statins and intracerebral hemorrhage outcomes is unclear.
We aimed to compare the in-hospital mortality and evacuation of intracranial hematoma rates in patients with primary intracerebral hemorrhage between prior statin users and nonusers.
The final study population included 66,263 patients. Multivariable logistics analyses showed that prior statin use was not associated with in-hospital mortality for primary intracerebral hemorrhage (adjusted odd ratio 0.78, 95% CI 0.61-1.01), but reduced the proportion of patients undergoing evacuation of intracranial hematoma (adjusted odd ratio 0.70, 95% CI 0.61-0.82). Propensity score matching analyses yielded similar results.
Prior statin use was not associated with in-hospital mortality but did reduce evacuation of intracranial hematoma rates.
他汀类药物与脑出血结局之间的关系尚不清楚。
我们旨在比较原发性脑出血患者中既往使用他汀类药物与未使用者的住院死亡率和颅内血肿清除率。
最终的研究人群包括 66263 名患者。多变量逻辑分析显示，既往使用他汀类药物与原发性脑出血的住院死亡率无关（调整后的优势比为 0.78，95%可信区间为 0.61-1.01），但降低了颅内血肿清除术的比例（调整后的优势比为 0.70，95%可信区间为 0.61-0.82）。倾向评分匹配分析得出了相似的结果。
既往使用他汀类药物与住院死亡率无关，但确实降低了颅内血肿清除率。
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