高空腹血糖与原发性脑出血患者住院临床结局恶化相关：来自一项大规模全国性纵向注册研究。
Higher fasting blood glucose was associated with worse in-hospital clinical outcomes in patients with primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry.
机构信息
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Neurocardiology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
出版信息
CNS Neurosci Ther. 2022 Dec;28(12):2260-2267. doi: 10.1111/cns.13972. Epub 2022 Sep 24.
INTRODUCTION
Studies that investigated the relationship between fasting blood glucose (FBG) and intracerebral hemorrhage (ICH) outcomes were insufficient.
AIM
We aimed to investigate the association between FBG level and in-hospital clinical outcomes in patients with primary ICH.
RESULTS
A total of 34,507 patients were enrolled in the final study. Compared with the reference group, the ≥6.1 and <7 mmol/L group showed nonsignificant higher in-hospital mortality (adjusted odds ratio [OR] 1.20, 95% confidence interval [CI] 0.69-2.11, p = 0.52), and a significant higher proportion of intracranial hematoma evacuation (adjusted OR 1.56, 95% CI 1.26-1.92, p < 0.001). The ≥7 mmol/L group showed both significant higher in-hospital mortality (adjusted OR 2.08, 95% CI 1.42-3.04, p = 0.52) and a significant higher proportion of intracranial hematoma evacuation (adjusted OR 2.09, 95% CI 1.78-2.47, p < 0.001).
CONCLUSION
Higher FBG level was correlated with both higher mortality and proportion of evacuation of intracranial hematoma.
简介
研究空腹血糖（FBG）与脑出血（ICH）结局之间关系的研究还不够充分。
目的
本研究旨在探讨原发性 ICH 患者 FBG 水平与住院临床结局之间的关系。
结果
共有 34507 例患者纳入最终研究。与参考组相比，≥6.1 且＜7mmol/L 组住院死亡率无显著升高（校正优势比 [OR] 1.20，95%置信区间 [CI] 0.69-2.11，p=0.52），颅内血肿清除术的比例显著升高（校正 OR 1.56，95%CI 1.26-1.92，p＜0.001）。≥7mmol/L 组住院死亡率显著升高（校正 OR 2.08，95%CI 1.42-3.04，p=0.52），颅内血肿清除术的比例也显著升高（校正 OR 2.09，95%CI 1.78-2.47，p＜0.001）。
结论
较高的 FBG 水平与较高的死亡率和颅内血肿清除率相关。
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