铜催化的喹喔啉-2(1H)-酮与苯磺酰基腙的 C-3 苄基化反应。

Copper-catalyzed C-3 benzylation of quinoxalin-2(1)-ones with benzylsulfonyl hydrazides.

机构信息

Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.

出版信息

Org Biomol Chem. 2022 Jun 8;20(22):4518-4521. doi: 10.1039/d2ob00744d.

DOI:10.1039/d2ob00744d

PMID:35604002

Abstract

An unprecedented use of benzylsulfonyl hydrazides as benzylating agents has been demonstrated in the direct C-3 benzylation of quinoxalin-2(1)-ones. A range of benzylsulfonyl hydrazides participated in the C-3 benzylation of quinoxalin-2(1)-ones with CuCN as the catalyst and DTBP as the oxidant, delivering structurally diverse 3-benzylquinoxalin-2(1)-ones in moderate to good yields.

摘要

苯磺酰基腙被首次用作苄基化试剂，用于喹喔啉-2(1H)-酮的直接 C-3 苄基化反应。一系列苯磺酰基腙在 CuCN 作为催化剂和 DTBP 作为氧化剂的条件下参与喹喔啉-2(1H)-酮的 C-3 苄基化反应，以中等至良好的收率得到结构多样的 3-苄基喹喔啉-2(1H)-酮。